Browsing by Author "Zamri, A."

Now showing 1 - 14 of 14
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    SINTESIS (E)-3-(4-HIDROKSIFENIL)-1-(NAFTALEN-1-IL)PROP-2-EN-1-ON DARI ASETILNAFTALEN DAN 4-HIDROKSIBENZALDEHID
    (2014-03-27) Putri, R. E.; Zamri, A.; Jasril
    Chalcone of (E) 3 (4 hydroxyfenil) 1 (naphthalene 1 il)prop 2 en 1 on has been synthesized from 1 acetylnaphthalene with 4 hydroxybenzaldehyde by microwave irradiation method with potassium hydroxide catalyst at room temperature. The yield of synthesized compound was 68.26% and characterized by using UV, IR, NMR and Mass spectroscopy. Data of characterization showed that compound that have been obtained was based on target compound
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    SINTESIS ANALOG KURKUMIN TURUNAN 1-BENZIL 4-PIPERIDINON MENGGUNAKAN KATALIS BASA DAN UJI AKTIVITAS SEBAGAI ANTIBAKTERI
    (2014-03-27) Wahyuni, S.; Eryanti, Y.; Zamri, A.; Jasril
    Curcumin is one of secondary metabolites with phenolic group which was known to have various biological activities such as antimicroba, anticancer, antioxidant, antitumor and anti-inflammatory activities. In this research, curcumin analog of 1-benzil-4- piperidone derivative was synthesized using microwave irradiation with catalyst NaOH. The rendement (YN2) resulted 99.39%. All compounds were characterized using UV spectrophotometer, IR spectrophotometer, 1 H NMR, and 13 C NMR spectrometers. The antibacterial activity was evaluated using the agar diffusion method. Antibacterial activity test was carried out at concentrations of 20, 30, 40, 50 , and 60 mg/disc against Gram positive bacteria (Staphylococcus aureus and Bacillus subtilis) and Gram negative bacteria (Escherichia coli and Salmonella enteritidis). YN 2 compounds obtained showed different antibacterial activity against different bacteria.
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    SINTESIS DAN UJI AKTIVITAS ANTIBAKTERI SENYAWA KURKUMIN (3E,5E)-3,5-BIS(2’-HIDROKSIBENZILIDIN)-1-METILPIPERIDIN-4 -ON
    (2014-03-27) Hasanah, U.; Zamri, A.; Balatif, N.; Eryanti, Y.
    The derivatives of curcumin are second ary metabolites belonging to the phenolic group. Some of them were reported to have biological activities such as anti -i nfl ammatory, anticancer and antioxidant activities. In this study, acurcumin of (3E,5E)-3,5bis(2’-hidroxybenzilidin)-1-metilpiperidin-4-one from 1-methyl-4-pi peridinone with 2-hydroxy benzaldehideh as been successfully synthesized using microwave irradiation method with NaOH (20 %) as catalyst . React ion was carried out for 1 minute at 180 watt . The compound resulted was in the form of yellow crystal withayield of 72 %. The compound was characterized by measuring its melting point, identifying by TLC, and elucidated by UV-Vis, FT- IR, MS, 1 H NMR, and 13 C NMR. Our result show edthatthecom pound had the target edmolecule structure. Ant i bacterial test was carried out using the agar di ffusion method against Staphylococcus aureus, Escherichia coli, Bacillus subtilis, and Salmonella enteritidis. Overall, inhibition zone ran ged from 6.5 t o 10 mm and showed avery weak activity.
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    SINTESIS DAN UJI TOKSISITAS BEBERAPA SENYAWA ANALOG PARA METOKSI KALKON
    (2013-03-07) Perdana, F.; Eryanti, Y.; Zamri, A.
    Chalcone is a very interesting compound because it is known to have various of biological activities such as antimicroba, antifungi, anesthetics, anticancer, antimalaria, antioxidance, antitumor and anti-inflammatory. Moreover, natural and synthetic compounds of chalcone have roles as precursors for other compounds. Therefore, many chalcones become model structures of target compounds by researcher. In this research, chalcone methoxy analogue compounds have been synthesized using stirer method and using base catalyst NaOH. The synthesized results obtained are (E)-3-(4- isopropylphenyl)-1-(4'-methoxyphenyl)prop-2-en-1-one (1), (E)-1-(4'-methoxyphenyl)- 3-p-tolylprop-2-en-1-one (2) and (E)-3-(3-bromophenyl)-1-(4'-methoxyphenyl)prop-2- en-1-one (3). The purity of all compounds have been tested using TLC, melting point test, analytical HPLC. Then they are characterized using UV, FTIR, 1H-NMR and MS spectroscopy. The toxicity test of the novel compounds was done by Brine Shrimp Lethality Test (BSLT) method. The all compounds showed very good activity with LC50 value < 200 μg/mL
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    SINTESIS DAN UJI TOKSISITAS SENYAWA ANALOG KALKON TURUNAN 3’,4’- DIMETOKSI ASETOFENON
    (2014-03-27) Sari, D. W. P.; Zamri, A.; Yuharmen
    Chalcone is one of secondary metabolites included into the class of flavonoids that are known to have biological activities. Chalcone can be used as an intermediate for synthesizing heterocyclic compounds, such as flavones, flavanols, flavanones, and others that also have biological activities. Chalcone generally can be synthesis by Claisen-Schmidth condensation from aldehide and ketone aromatic using acid or base catalyst. Chalcone compound 3,4’- dimetoxy acetophenone derivative was synthesis using the microwave with a base catalyst (KOH). The yield obtained from each of chalcone analogs are (E)-1-(3,4-dimetoxy phenil)-3-(4-hidroxy phenil)prop-2-en-1-one (M1) with value 36,5%, (E)-1-(3,4-dimetoxy phenil)-3-(3-hidroxy phenil)prop-2-en-1- one (M2) with value 93,3% and (E)-1-(3,4-dimetoxy phenil)-3-(2-hidroxy phenil)prop- 2-en-1-one (M3) with value 57,3%. The characterization of all compounds have been tested using UV-Vis. IR, 1H NMR and MS. The toxicity test was done by Brine Shrimp Lethality Test (BSLT) method using Artemia salina Leach. The compound of M1, M2 and M3 showed that value LC50 in sequence are 41,687 μg/mL; 253,513 μg/mL and 29,512 μg/mL. Two analogs of chalcone compounds are positive as anticancer proved by LC50 values <200 μg/mL and one compound is negative as anticancer proved by LC50 value > 200 μg/mL
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    SINTESIS DAN UJI TOKSISITAS SENYAWA ANALOG KURKUMIN TURUNAN 1-METIL-4-PIPERIDINON
    (2013-07-19) Hidayah, N.; Eryanti, Y.; Zamri, A.
    Curcumin is one of secondary metabolites included into the class of group fenolic which was known to have biological activity such as anticancer, antioxidant, antidiabetic, and anti-inflammatory. Therefore , curcumin becomes model of target compounds that have various structure. In this research, curcumin analog coumponds of 1- methyl-4- piperidone derivative were synthesized using microwave irradiation with a base catalyst (NaOH). The rendement obtained from each of curcumin analogs are (3E,5E)-3,5-bis (2-chlorobenzilidyn)-1-methylpiperidyn-4-one (1) with value 38,86 %, (3E,5E)-3,5-bis (4-chlorobenzilidyn)-1-methylpiperidyn-4-one (2) with value 65,60 % dan (3E,5E)-3,5-bis (3-bromobenzilidyn)-1-methylpiperidyn-4-one (3) with value 19,73%. The purity of all compounds has been tested using TLC, melting point test, and analytical HPLC. The identification of curcumin analog coumponds was analysed using UV, IR, 1H NMR and MS. The toxicity test done by Brine Shrimpt Lethality Test (BSLT) method to artemia salina Leach larva showed that LC50 < 200 μg/mL. The result toxicity test to all of compounds showed that the coumpond(1) is the most toxic compared to (2) and (3).
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    SINTESIS DAN UJI TOKSISITAS SENYAWA KALKON (E)-1-(2- HIDROKSIFENIL)-3-(4-METOKSIFENIL)PROP-2-EN-1-ON
    (2014-03-27) Sofiana, A.; Balatif, N.; Zamri, A.
    Chalcone of (E)-1-(2-hydroxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one has been synthesized by stirring 2’-hydroxyacetophenon with methoxybenzaldehide derivatives in polyethylene glycol (PEG-400) at room temperature according to Claisen-Schmidt condensation. In this research KOH is used as catalyst. The rendement obtained was 76% and the structure was confirmed by UV, IR, 1H-NMR and MS spectroscopy. The toxicity was evaluated by Brine Shirmp Lethality Test (BSLT) method againts larvae of Artemia salina Leach. The chalcone had good toxicity activity since its LC50 was 0.666 μg/m
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    SINTESIS DAN UJI TOKSISITAS SENYAWA KALKON ANALOG 2,5-DIMETOKSIBENZALDEHID
    (2014-03-27) Hidayat, T.; Zamri, A.; Yuharmen
    Chalcones are a class of α,ß-unsaturated carbonyl compounds that forms the central core of various naturally occurring biologically active compounds. They exhibit tremendous potential to act as a pharmacological agent. It has been reported that they were active as antioxidant, antifungal, antibacterial, antidepressant, anticancer, anti-inflammatory and other biological activities. The chalcone analogue of 2,5-dimetoxibenzaldehyde ((E)-3-(2,5dimetoksifenil)-1-(4-hidroksifenil)prop-2-en-1-on) was synthesized and tested for its toxicity using Brine Shrimp Lethality Test (BSLT) method. The purity of compound has been tested using TLC, melting point test, analytical HPLC. It was then characterized using UV, IR, 1 H-NMR and MS spectroscopy. LC50 value of toxic compound is <200µg/mL. Our result showed that (E)-3-(2,5-dimetoksifenil)-1-(4-hidroksifenil)prop-2-en-1-on compound was not potential as an anticancer since its LC50 was 1949 µg/mL.
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    SINTESIS SENYAWA KALKON TURUNAN 3’,4’-DIMETOKSI ASETOFENON DAN UJI TOKSISITAS MENGGUNAKAN METODE BRINE SHRIMP LETHALITY TEST (BSLT)
    (2013-07-19) Hastiningrum, W. P.; Eryanti, Y.; Zamri, A.
    Three new chalcones of 3’,4’-dimethoxy acetophenone derivative were synthesized by stirrer method with alkaline sodium hydroxide catalyst at room temperature. They were (E) -1,3-bis (3,4 dimetoksifenil) prop-2-en-1-one (CA1), (E) -3 - (2,3 -dimetoksifenil) -1 - (3,4-dimetoksifenil) prop-2-en-1-one (CA2) and (E) -3 - (2,4,5-trimetoksifenil) -1 - (3,4-dimetoksifenil ) prop-2-en-1-one (CA3). Chalcone yield compounds obtained were 98%, 84.24% and 79.13%, respectively. The compounds were identified using UV spectroscopy, IR, 1H NMR and MS. Toxicity of chalcones tested using Brine Shrimp Lethality Test (BSLT) against larvae of Artemia salina Leach. CA1, CA2 and CA3 compounds had LC50 i.e., 17.022 mg / mL, 4.645 mg / mL and 648.634 mg / mL, respectively . The result showed that CA1 and CA2 were toxic as their LC50 values less than 200 mg / mL, while CA3 was found to be non- toxic compound.
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    SINTESIS SENYAWA KURKUMIN TURUNAN 1-BENZIL-4-PIPERIDINON DAN UJI TOKSISITAS DENGAN METODE BRINE SHRIMP LETHALITY TEST (BSLT)
    (2013-07-19) Wahyuni, E.; Eryanti, Y.; Zamri, A.
    Curcumin is one of secondary metabolites classified into the class of fenolic that are known to have biological activities such as anti-oxidant, anti-diabetic, anti-inflammatory and anti-cancer. Therefore, many curcumins become model of target compounds with variation structure. Curcumins of 1-benzyl-piperidin-4-on derivative were synthesized using the microwave irradiation with a base catalyst (NaOH) and an acid catalyst metanasulfonat. The rendement result of curcumins analog were as followed: (3E,5E)-3,5-bis(2’-klorobenzilidin)-1-benzil-4-piperidinone (1) about 93,03%, (3E,5E)-3,5-bis(4’-klorobenzilidin)-1-benzil-4-piperidinone (2) about 14,40% and (3E,5E)-3,5-bis(3’-bromobenzilidin)-1-benzil-4-piperidinone (3) about 33%. The purity of all compounds has been tested using TLC, melting point test and analytical HPLC. Then, they were identified using UV, IR, 1NMR and MS spectroscopy. The toxicity test of curcumins was done by Brine Shrimp Lethality Test (BSLT) method which was indicated by LC50 <200 μg/mL. Between the three analog curcumins only (1) has potensial as anti-cancer by LC50= 22,44 μg/mL.
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    SINTESISDAN UJI TOKSISITAS SENYAWA ANALOG KURKUMIN TURUNAN 4-PIPERIDINON
    (2014-03-27) Nurwantari, W.; Eryanti, Y.; Jasril; Zamri, A.
    Curcumin is one of secondary metabolites included into the fenolic group which was known to have various of biological activities such as antimicroba, anticancer, antioxidance, antitumor and anti-inflammatory. Therefore, curcumin through the variation of thestructurecould became amodel for target molecule. In this research, curcumin analog coumpond of 4-piperidone derivative was synthesized using microwave irradiation withan acid catalyst (SOCl2). The rendement resultedfrom curcumin analog is(3E,5E)-3,5-bis (2-chlorobenzilidyn)-piperidyn-4-one(1) 94,35%. The purity ofompoundhas been tested using TLC, melting pointtest, and analytical HPLC.The compoundresulted was characterized usingUV, IR, 1 H NMR and 13 C NMR.The toxicity test done by Brine ShrimpLethality Test(BSLT) method toArtemia salinaLeach larvagaveLC50 value< 200 μg/mL.The resultshowedthatcompound(1) haspotential asananticancerwithLC50 value= 55,46µg/mL.
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    SINTESISDANUJITOKSISITASANALOG3’-BROMOKALKON
    (2014-03-27) Rahmadhona, S.; Balatif, N.; Zamri, A.
    Chalconeof1-(3’-Bromofenil)-3-(4’-Klorofenil)-2 propen-1-on has beensynthesized from3’-bromoasetofenonbystirrermethodandevaluatedfor its toxicity activity. 1-(3’-Bromofenil)-3-(4’-Klorofenil)-2-propen1-onshowedagoodyield, andthen it was characterizedusingUVspectroscopy, IR and 1 H-NMR. Its toxicity activityhasbeen identified usingBrineShrimpLethalityTest(BSLT)againstlarvae ofArtemiasalina Leach. The toxicity value of 1-(3’-Bromofenil)-3-(4’-Klorofenil)-2-propen-1-on obtainedwas1,03mg/ mL. It indicated that the chalconehadagoodtoxicity and potentialasanticancer.
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    SINTESISDANUJITOKSISITASSENYAWAANALOG 3’,4’-DIMETOKSIKALKON
    (2014-03-27) Novianti, S.; Balatif, N.; Zamri, A.
    Chalconesbelongto important classofflavonoid compounds.Theyhavealsobeen reported to have anticancer, antimicrobial, antifungal, antioxidant, and cytotoxic activities. In this research, an analogous chalcone of(E)-3-(4clorophenyl)-1-(3’,4’ dimetoxyphenyl) prop- 2-en-1-on wassynthesized using microwaveiradiation and natriumhidroxideas catalyst. Thecompound showed a goodyield,and then was characterizedbyUVspectroscopy,IR, 1 H-NMR,andMassSpectroscopy.Its toxicity hasbeenidentified usingBrineShrimpLethalityTest(BSLT) methodonArtemia salina Leach. The result showed that it had a good toxicity activity with LC50=2.24µg/mLandpotentialasanticancer.
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    SINTESISDANUJITOKSISITASSENYAWAKALKON TURUNAN4’–METILASETOFENON
    (2014-03-27) Tillah, M.; Yuharmen; Zamri, A.
    (E)-3-(4-chlorophenyl)-1-p-tolylprop-2-en-1-one has been synthesized from 4’-methylacetophenoneand4 chlorobenzaldehydeusingNaOH(5%) asacatalystby Claisen Schmidt condensation in good yield.The product has been determined,interm of its melting point,identified byKLT,then elutedwithUV-Vis,FT-IR,MS,and 1H-NMR.Chalcones compound toxicity test was done using Brine Shrimp LethalityTest (BSLT)method against larvae Artemia salina Leach.LC50 value for compound(E)-3- (4-chlorophenyl)-1-p-tolylprop-2-en-1-one is 2,81 µg/mL. The analog chalcone compound are positively potential as anti-cancer.