SINTESISDAN UJI TOKSISITAS SENYAWA ANALOG KURKUMIN TURUNAN 4-PIPERIDINON
No Thumbnail Available
Date
2014-03-27
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Curcumin is one of secondary metabolites included into the fenolic group which was known to have various of biological activities such as antimicroba, anticancer, antioxidance, antitumor and anti-inflammatory. Therefore, curcumin through the variation of thestructurecould became amodel for target molecule. In this research, curcumin analog coumpond of 4-piperidone derivative was synthesized using
microwave irradiation withan acid catalyst (SOCl2). The rendement resultedfrom curcumin analog is(3E,5E)-3,5-bis (2-chlorobenzilidyn)-piperidyn-4-one(1) 94,35%.
The purity ofompoundhas been tested using TLC, melting pointtest, and analytical HPLC.The compoundresulted was characterized usingUV, IR, 1 H NMR and 13 C NMR.The toxicity test done by Brine ShrimpLethality Test(BSLT) method toArtemia salinaLeach larvagaveLC50 value< 200 μg/mL.The resultshowedthatcompound(1) haspotential asananticancerwithLC50 value= 55,46µg/mL.
Description
Keywords
Brine Shrimp Lethality Test(BSLT), curcumin, toxicity test