SINTESISDAN UJI TOKSISITAS SENYAWA ANALOG KURKUMIN TURUNAN 4-PIPERIDINON
| dc.contributor.author | Nurwantari, W. | |
| dc.contributor.author | Eryanti, Y. | |
| dc.contributor.author | Jasril | |
| dc.contributor.author | Zamri, A. | |
| dc.date.accessioned | 2014-03-27T07:14:08Z | |
| dc.date.available | 2014-03-27T07:14:08Z | |
| dc.date.issued | 2014-03-27 | |
| dc.description.abstract | Curcumin is one of secondary metabolites included into the fenolic group which was known to have various of biological activities such as antimicroba, anticancer, antioxidance, antitumor and anti-inflammatory. Therefore, curcumin through the variation of thestructurecould became amodel for target molecule. In this research, curcumin analog coumpond of 4-piperidone derivative was synthesized using microwave irradiation withan acid catalyst (SOCl2). The rendement resultedfrom curcumin analog is(3E,5E)-3,5-bis (2-chlorobenzilidyn)-piperidyn-4-one(1) 94,35%. The purity ofompoundhas been tested using TLC, melting pointtest, and analytical HPLC.The compoundresulted was characterized usingUV, IR, 1 H NMR and 13 C NMR.The toxicity test done by Brine ShrimpLethality Test(BSLT) method toArtemia salinaLeach larvagaveLC50 value< 200 μg/mL.The resultshowedthatcompound(1) haspotential asananticancerwithLC50 value= 55,46µg/mL. | en_US |
| dc.description.sponsorship | Eryanti, Y., Jasril., Zamri, A | en_US |
| dc.identifier.other | Rangga Dwijunanda Putra | |
| dc.identifier.uri | http://repository.unri.ac.id/xmlui/handle/123456789/5955 | |
| dc.language.iso | other | en_US |
| dc.subject | Brine Shrimp Lethality Test(BSLT) | en_US |
| dc.subject | curcumin | en_US |
| dc.subject | toxicity test | en_US |
| dc.title | SINTESISDAN UJI TOKSISITAS SENYAWA ANALOG KURKUMIN TURUNAN 4-PIPERIDINON | en_US |
| dc.type | Other | en_US |