SINTESIS ANALOG KURKUMIN TURUNAN 1-BENZIL 4-PIPERIDINON MENGGUNAKAN KATALIS BASA DAN UJI AKTIVITAS SEBAGAI ANTIBAKTERI
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Date
2014-03-27
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Abstract
Curcumin is one of secondary metabolites with phenolic group which was known to
have various biological activities such as antimicroba, anticancer, antioxidant, antitumor
and anti-inflammatory activities. In this research, curcumin analog of 1-benzil-4-
piperidone derivative was synthesized using microwave irradiation with catalyst NaOH.
The rendement (YN2) resulted 99.39%. All compounds were characterized using UV
spectrophotometer, IR spectrophotometer, 1 H NMR, and 13 C NMR spectrometers. The
antibacterial activity was evaluated using the agar diffusion method. Antibacterial
activity test was carried out at concentrations of 20, 30, 40, 50 , and 60 mg/disc against Gram positive bacteria (Staphylococcus aureus and Bacillus subtilis) and Gram
negative bacteria (Escherichia coli and Salmonella enteritidis). YN 2 compounds
obtained showed different antibacterial activity against different bacteria.
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Keywords
Antibacterial, curcumin, irradiation microwave