SINTESISDANUJITOKSISITASSENYAWAANALOG 3’,4’-DIMETOKSIKALKON
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Date
2014-03-27
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Abstract
Chalconesbelongto important classofflavonoid compounds.Theyhavealsobeen reported to have anticancer, antimicrobial, antifungal, antioxidant, and cytotoxic activities. In this research, an analogous chalcone of(E)-3-(4clorophenyl)-1-(3’,4’ dimetoxyphenyl) prop- 2-en-1-on wassynthesized using microwaveiradiation and
natriumhidroxideas catalyst. Thecompound showed a goodyield,and then was characterizedbyUVspectroscopy,IR, 1 H-NMR,andMassSpectroscopy.Its toxicity hasbeenidentified usingBrineShrimpLethalityTest(BSLT) methodonArtemia salina Leach. The result showed that it had a good toxicity activity with
LC50=2.24µg/mLandpotentialasanticancer.
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3’,4’-dimetoxyacetophenone, BSLT, chalcones, toxicity