SINTESIS SENYAWA 4-(1-(4-FLUOROFENIL)-5-(3-METOKSIFENIL)- 4,5-DIHIDRO-1H-PIRAZOL-3-IL) FENOL
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Date
2024-01
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Elfitra
Abstract
Pyrazoline has two nitrogen atoms adjacent to each other in its ring and possess only
one endocyclic double bond. The pyrazoline compound 4-(1-(4-Fluorophenyl)-5-(3-
Methoxyphenyl)-4,5-Dihydro-1H-Pirazol-3-yl) phenol and named as P3OME-4OH-4F
has been successfully synthesized through three stages reaction. The first stage is the
formation of the chalcone compound through the Claisen-Schmidt condensation
reaction with a yield of 54%, the second stage is the formation of the hydrazine
compound through diazotation and reduction reactions with a yield of 84% and the final
stage is the formation of the P3OME-4OH-4F compound through a cyclization reaction
with a yield obtained of 52%. The purity of the compound was tested by measuring the
melting point, TLC and HPLC analysis. The structure of the P3OME-4OH-4F
compound was confirmed by characterization using UV spectroscopy and FTIR.
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Keywords
chalcone, pyrazoline, spectroscopy
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