SINTESIS SENYAWA KONJUGASI KALKON (E)-1-(4-((1-(7- KLOROKUINOLIN-4-IL)-1H-1,2,3-TRIAZOL-4-IL)METOKSI)-2- HIDROKSI)-3-(4-METOKSIFENIL)PROP-2-EN-1-ON
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Date
2022-12
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Elfitra
Abstract
Organic synthesis has now developed into one of the most important aspects and the main
driving force of organic chemistry. With synthesis, natural products can be produced on a
large scale in an easy and low-cost way. Through the isolation of natural materials in the
modern era and technological advances today, it is possible to synthesize new medicinal
compounds based on structural modifications of previously discovered medicinal
compounds through the isolation of natural materials. One of them is the synthesis of
chalcone compounds (E)-1-(4-((1-(7-chloroquinoline-4-yl)-1H-1,2,3-triazole-4-
yl)methoxy)-2-hydroxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one via chalcone
modification by incorporating a chloroquinoline group with a triazole linker molecule.
Synthesis was carried out convergently through the formation of chloroquinoline azide
compounds and the formation of propargyl substituted chalcone compounds. These two
compounds are then combined through the formation of a linking compound, namely
triazole, which is carried out by "click chemistry". The yield obtained from the chalcone
synthesis was 28.90 %. The interpretation results of UV, FTIR, 1H-NMR, 13C-NMR and
HRMS data indicated that the synthesized compound was compound (E)-1-(4-((3-(1-(7-
chloroquinoline-4-yl) triaz-2-en-1-yl))prop-2-un-1-yl)oxy)-2-hydroxyphenyl)-3-(4-
methoxyphenyl) prop-2-en-1-one. This compound is an intermediate compound of the
target molecule.
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Keywords
Chalcone, click chemistry, quinoline, triazole
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