SINTESIS SENYAWA KONJUGASI KALKON (E)-1-(4-((1-(7- KLOROKUINOLIN-4-IL)-1H-1,2,3-TRIAZOL-4-IL)METOKSI)-2- HIDROKSI)-3-(4-METOKSIFENIL)PROP-2-EN-1-ON

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dc.contributor.authorRabby, Rahmad Setiawan
dc.contributor.supervisorZamri, Adel
dc.date.accessioned2023-03-14T02:35:12Z
dc.date.available2023-03-14T02:35:12Z
dc.date.issued2022-12
dc.description.abstractOrganic synthesis has now developed into one of the most important aspects and the main driving force of organic chemistry. With synthesis, natural products can be produced on a large scale in an easy and low-cost way. Through the isolation of natural materials in the modern era and technological advances today, it is possible to synthesize new medicinal compounds based on structural modifications of previously discovered medicinal compounds through the isolation of natural materials. One of them is the synthesis of chalcone compounds (E)-1-(4-((1-(7-chloroquinoline-4-yl)-1H-1,2,3-triazole-4- yl)methoxy)-2-hydroxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one via chalcone modification by incorporating a chloroquinoline group with a triazole linker molecule. Synthesis was carried out convergently through the formation of chloroquinoline azide compounds and the formation of propargyl substituted chalcone compounds. These two compounds are then combined through the formation of a linking compound, namely triazole, which is carried out by "click chemistry". The yield obtained from the chalcone synthesis was 28.90 %. The interpretation results of UV, FTIR, 1H-NMR, 13C-NMR and HRMS data indicated that the synthesized compound was compound (E)-1-(4-((3-(1-(7- chloroquinoline-4-yl) triaz-2-en-1-yl))prop-2-un-1-yl)oxy)-2-hydroxyphenyl)-3-(4- methoxyphenyl) prop-2-en-1-one. This compound is an intermediate compound of the target molecule.en_US
dc.description.sponsorshipFakultas Matematika dan Ilmu Pengetahuan Alamen_US
dc.identifier.citationPerpustakaanen_US
dc.identifier.otherElfitra
dc.identifier.urihttps://repository.unri.ac.id/handle/123456789/10893
dc.language.isoenen_US
dc.publisherElfitraen_US
dc.subjectChalconeen_US
dc.subjectclick chemistryen_US
dc.subjectquinolineen_US
dc.subjecttriazoleen_US
dc.titleSINTESIS SENYAWA KONJUGASI KALKON (E)-1-(4-((1-(7- KLOROKUINOLIN-4-IL)-1H-1,2,3-TRIAZOL-4-IL)METOKSI)-2- HIDROKSI)-3-(4-METOKSIFENIL)PROP-2-EN-1-ONen_US
dc.typeArticleen_US

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