Abstract:
Pyrazoline is a five-ring heterocyclic compound which has two nitrogen atoms close
together in the ring and has only one endocyclic double bond. Pyrazoline analogue
5-(4-fluorophenyl) -3- (2-hydroxynaphthalene-2-yl) -1-phenyl-4,5-dihydro-1H-pyrazole
(PF-NH2-4F) is synthesized by cyclization reaction of chalcone compounds
3-(4-fluorophenyl) -1- (2-hydroxy naphthalene -2-yl) -2- propen -1-one with phenyl
hydrazine. Synthesis of the pyrazoline using monowave, at a temperature of 80oC for 2
hours. The purity of the compound was determined using TLC test, melting point
measurement and HPLC analysis. The structure of the synthesized compound was
confirmed by means of UV-Vis and FTIR. The yield resulting from the synthesis of the
compound PF-NH2-4F was 47.42%. The activity test of pyrazoline compounds was
determined by the BSLT method using shrimp larvae (Artemia salina Leach) which
obtained an LC50 value of 7.88 μg/mL, which are considered to have moderate levels of
toxicity due to their toxicity activity have LC50 values >1 μg/mL and <100 μg/mL
