SINTESIS DAN UJI TOKSISITAS SENYAWA 5-(4-FLOROFENIL)-3-(2- HIDROKSINAFTALEN-2-IL)-1-FENIL-4,5-DIHIDRO-1H-PIRAZOL

Simple item page
dc.contributor.authorNingsih, Winda Ayu
dc.contributor.supervisorJasril, Jasril
dc.date.accessioned2022-03-15T03:40:35Z
dc.date.available2022-03-15T03:40:35Z
dc.date.issued2021-10
dc.description.abstractPyrazoline is a five-ring heterocyclic compound which has two nitrogen atoms close together in the ring and has only one endocyclic double bond. Pyrazoline analogue 5-(4-fluorophenyl) -3- (2-hydroxynaphthalene-2-yl) -1-phenyl-4,5-dihydro-1H-pyrazole (PF-NH2-4F) is synthesized by cyclization reaction of chalcone compounds 3-(4-fluorophenyl) -1- (2-hydroxy naphthalene -2-yl) -2- propen -1-one with phenyl hydrazine. Synthesis of the pyrazoline using monowave, at a temperature of 80oC for 2 hours. The purity of the compound was determined using TLC test, melting point measurement and HPLC analysis. The structure of the synthesized compound was confirmed by means of UV-Vis and FTIR. The yield resulting from the synthesis of the compound PF-NH2-4F was 47.42%. The activity test of pyrazoline compounds was determined by the BSLT method using shrimp larvae (Artemia salina Leach) which obtained an LC50 value of 7.88 μg/mL, which are considered to have moderate levels of toxicity due to their toxicity activity have LC50 values >1 μg/mL and <100 μg/mLen_US
dc.description.sponsorshipDosen Bidang Kimia Organik Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Riauen_US
dc.identifier.otherwahyu sari yeni
dc.identifier.urihttps://repository.unri.ac.id/handle/123456789/10497
dc.language.isoenen_US
dc.publisherperpustakaan URen_US
dc.subjectmonowaveen_US
dc.subjectpyrazolineen_US
dc.subjecttoxicityen_US
dc.titleSINTESIS DAN UJI TOKSISITAS SENYAWA 5-(4-FLOROFENIL)-3-(2- HIDROKSINAFTALEN-2-IL)-1-FENIL-4,5-DIHIDRO-1H-PIRAZOLen_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Winda Ayu Ningsih _compressed.pdf
Size:
199.98 KB
Format:
Unknown data format
Description:
artikel
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Chemical