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Browsing by Author "Zamri, Adel"

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ISOLASI MINYAK ATSIRI DAUN KEMANGI (Ocimum sanctum L) CARA KONVENSIONAL DAN MICROWAVE SERTA UJI AKTIVITAS ANTIBAKTERI DAN ANTIOKSIDAN
(2016-10-19) Anwar, Arief Khaerul; Yuharmen; Zamri, Adel
The aim of this study was to isolate essential oils from Ocimum sanctum L leaves by Clevenger-hydrodistillation and microwave-assisted hydrodistillation. Components of the essential oil were then identified using Gas Chromatography Mass Spectrometry (GC-MS). Antimicrobial activity of these oils was determined by this diffusion method against Escherichia coli, the main component of the essential oils was geranial (24.74%) and neral (28.11%) for Clevenger-hydrodistillation method, while geranial (41.85%) and neral (29.07%) for the method microwave-assisted hydrodistillation. Our finding for antimicrobial test showed that essential oil of microwave-assisted hydrodistillation was more active than those of Clevenger-hydrodistillation. Antioxidant activity using DPPH assay of the essential oil of Clevenger-hydrodistillation was more active (IC50=513.1802 μg/mL) than those of microwave-assisted hydrodistillation (IC50=713.2279 μg/mL).
MANAJEMEN PENGELOLAAN LIMBAH CAIR MINYAK BUMI DI DUMAI
(2016-07-21) Asmiwati; Mulyadi, Aras; Zamri, Adel; Mubarak
Kegiatan industri secara umum mengasilkan Produk yang diinginkan juga sebahagian yang tidak diinginkan merupakan sektor yang sangat potensial sebagai sumber pencemaran yang akan merugikan bagi kesehatan dan lingkungan. Pencemaran berasal dari industri merupakan buangan limbah dari industri hasil akhir proses produksi yang tidak memiliki nilai namun memiliki potensi bahaya bagi lingkungan. Limbah industri dapat berupa gas, cair maupun padat yang dapat berpengaruh terhadap lingkungan dan kesehatan manusia bila tidak ditangani dengan baik dan benar tujuan penelitian ini untuk melihat manajemen pengelolaan limbah cair minyak bumi. Terdiri dari plan skor 4.03 kriteria sangat bai. Do skor 3.75 kriteria baik, Check skor 3.73 kriteria baik dan action skor 4.06 kriteria sangat baik. Rata-rata skor 3.81 kriteria baik pengelolaan IPAL Pertamina Dumai perlu ditingkatkan manajemen Pengelolaan limbah cair minyak bumi yang pengelolaannya sudah sesui dengan baku mutu tetapi masih perlu manajemen pengolahan limbah cair minyak bumi supaya limbah yang dihasilkan dapat mendekati angka nol (Zero Waste Water) sehingga pencemaran lingkungan dapat diatasi.
Peranan Kimia Organik dalam Memenuhi Kebutuhan Umat Manusia: Tantangan dan Prospek Ke Depan
(2012-11-09) Zamri, Adel
Istilah organik berasal dari kata organisme atau benda hidup. Hal ini dikaitkan dengan kepercayaan para ahli kimia pada abad ke 18, dimana senyawa organik hanya bisa diperoleh melalui benda hidup dan proses pembentukannya dilakukan oleh adanya semacam gaya gaib (vital force). Karena itulah, banyak ahli kimia pada masa tersebut tidak mencoba membuat senyawa organik di laboratorium. Awal perubahan dimulai pada tahun 1828, ketika ahli kimia Jerman Frederich Wohler, secara kebetulan membuat urea, unsur penting dalam urin melalui pemanasan zat anorganik yaitu ammoniumsianat. Setelah penemuan itu, Wohler menulis surat pada gurunya, ahli kimia Swedia J. J. Berzelius sebagai berikut: “Saya dapat membuat urea tanpa memerlukan ginjal manusia atau hewan”. Kalimat ini menjadi sangat terkenal dan merupakan tonggak sejarah perkembangan kimia organik modern. Pada awalnya, Berzelius tidak mau menerima kenyataan yang ditemukan oleh muridnya. Namun setelah sintesis asam asetat (Kolbe, 1845), glukosa (Fischer, 1890), kamfer (Komppa, 1903) dan sintesis molekul lain barulah cerita vital force berakhir.
SINTESIS ANALOG KALKON TURUNAN 3’-HIDROKSIASETOFENON DAN METOKSIBENZALDEHID MENGGUNAKAN METODE IRADIASI MICROWAVE
(2016-10-19) Nurhalis, Mukhsin; Jasril; Zamri, Adel
Chalcone (E)-1-(3’-hidroxyphenyl)-3-(3-methoxysiphenyl)prop-2-en-1-one (MN) have been synthesized by Claisen–Schmidt condensation using potassium hydroxide as a catalyst under microwave irradiation. The reactions took placed in a short time (4 minutes) with a satisfying yield (55-96%). The chalcone structure was characterized based on the interpretation of spectroscopic data included UV, FTIR, 1H NMR and HRMS.
Sintesis Dan Aktivitas Antimikrobial Beberapa Turunan Pirazolin
(2015-07-02) Zamri, Adel; Yuharmen; Eryanti, Yum
Scnyawa turunan pirazolin telah lama dikenal mempunyai aktivitas biologi yang beragam seperti obat penenang, antihipertensi, sitotoksik. Ahli depsresi dan anti kanker. Beberapa diantaranya juga dilaporkan mempunyai aktivitas sebagai analgesic, antipiretik, dan antimikroba. Sifat antimikroba yang diiringi dengan dengan sifat analgesik dan antipiretik adalah sangat jarang ditemukan dalam satu senyawa, karena itu senyawa pirazolin menarik untuk diteliti dan dikaji lebiii lanjut. Untuk maksud tersebut diperlukan pirazolin dalam jumlah yang cukup dan variasi struktur yang lengkap. Hal ini sulit diperoleh melalui isolasi dari dari bahan alam (tumbuhan dan hewan), karena itu sintesis merupakan salah satu cara yang efektif untuk membantu penyediaan senyawa tersebut dalam jumlah yang diinginkan. : Dalam jangka panjang penelitian ini bertujuan untuk membentuk perpustakaan molekul pirazolin. Target khusus yang ingin dicapai pada tahap ini adalah menghasilkan 15 molekul pirazolin beserta sifat fisiko-kimia dan aktivitas antimikrobanya. Pada kesempatan ini telah dilakukan sintesis turunan pirazolin dan sekaligus dilaporkan sifat fisiko-kimianya dan sifat biologinya sebagai antimikroba.
SINTESIS DAN STUDI MOLECULAR DOCKING SENYAWA 3-(3-3- METOKSIFENIL)-1-FENIL-4,5-DIHIDRO- 1H-PIRAZOL-5-IL) FENOL SEBAGAI INHIBITOR ENZIM TIROSINASE
(Elfitra, 2022-03) Apriyani, Yuhana; Zamri, Adel
Hyperpigmentation is a darkening of the skin color caused by an increase in melanin production. Darkening of the skin occurs due to the formation of the pigment melanin in the skin through the oxidation of tyrosine which is assisted by the enzyme tyrosinase L-DOPA which will eventually form the pigment melanin. In general, the amount of melanin in the skin will determine our skin color. Tyrosinase is an enzyme that regulates melanin biosynthesis. Melanin formation can be inhibited by reducing tyrosinase synthesis or inhibiting its activity. One of the compounds that has acted an inhibitor of the tyrosinase enzyme is pyrazoline. Pyrazoline is a heterocyclic compound with two nitrogen atoms adjacent in a ring of five. The compound 3-(3-3- methoxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole-5-yl)phenol was synthesized using a monowave apparatus. The purity of the target compound was analyzed by TLC test, melting point measurement, and HPLC. The synthesized compounds were then structurally confirmed by UV, FTIR, 1H-NMR, and HRMS spectroscopy. The yield obtained from the synthesis of pyrazoline compounds is 75%. The synthesized pure compound was tested for activity as a tyrosinase inhibitor by molecular docking (in silico) and in vitro studies. Molecular docking studies were carried out on the crystal structure of tyrosinase (PDB ID: 2Y9X) with natural ligands tropolone and kojic acid as positive controls. The docking results showed that the pyrazoline compound had free bond energy (S score) = -11.0206 kcal/mol, while the free bond energy for kojic acid was -7.4610 kcal/mol.
SINTESIS DAN STUDI MOLECULAR DOCKING SENYAWA KALKON (E)-3-FENIL-1-(3-(4-(PIROLIDIN-1-IL)BUTOKSI)FENIL)PROP-2-EN-1- ON SEBAGAI INHIBITOR ENZIM TIROSINASE
(perpustakaan UR, 2021-06) Rahmatullah, Fadhilah; Zamri, Adel
Chalcones are composed of two benzene rings connected by a carbon α,β-unsaturated carbonyl structure and has various bioactivity, such as antibacterial, anticancer, antioxidant and inhibitor tyrosinase. For the further development of chalcone compounds, this research has carried out the synthesis of chalcone derivatives and the determination of their activity as a tyrosinase inhibitor through the in silico (molecular docking) approach. This chalcone derivative was synthesized by Claisen-Schmidt condensation between benzaldehyde and 3- hydroxy acetophenone. The chalcone compound was reacted with 1,4-dibromobutane and followed by a substitution reaction of the bromo with the pyrolidine. The structure of synthesized compounds were confirmed by spectroscopy analysis of UV and FTIR. Molecular docking studies were carried out on the crystal structure of tyrosinase (PDB ID: 2Y9X) and kojic acid as positive control. This target compound shows the free energy binding of -13.6379 kcal / mol, while kojic acid -8.3470 kcal/mol. The lower free energy binding value, the better compound were used in inhibiting of tyrosinase enzyme. Thus, it can be seen that the target compound is thought to be potential candidates for tyrosinase inhibitors.
SINTESIS DAN STUDI MOLECULAR DOCKING SENYAWA PIRAZOLIN DAN PIRAZOL TURUNAN 2-HIDROKSIASETOFENON DAN 2-KLOROBENZALDEHID SEBAGAI INHIBITOR ENZIM TIROSINASE
(perpustakaan UR, 2021-10) Sianturi, Artha Tirani; Zamri, Adel
The hyperpigmentation caused by melanin production excessive on the skin. So the prevention of hyperpigmentation can be done through the use of a cream containing an inhibitor of tyrosinase. One of the compounds that have activity as inhibitors of the enzyme tyrosinase is pirazolin and pirazol. Pyrazoline and pyrazole are heterocyclic compounds containing two nitrogen atoms, that have various activities such as antimicrobial, anticancer, antidiabetic, anti-inflammatory and tyrosinase inhibitors. Pyrazoline and pyrazole derivatives of 2-hydroxyacetophenone and 2-chlorobenzaldehyde were synthesized through pyrazoline cyclization synthesis and followed by an oxidative aromatization reaction. The structure of the synthesized compounds were confirmed through spectroscopic analysis of UV, FTIR, 1H-NMR and HRMS. The yield obtained from the synthesis of pyrazoline and pyrazole compound were 65,39 % and 26,08 %. Pyrazoline and pyrazole compounds were tested for their activity as a tyrosinase inhibitor through molecular docking studies. Molecular docking studies were carried out on the crystal structure of tyrosinase (PDB ID: 2Y9X) with natural ligands tropolone and kojic acid as positive controls. The docking results show that the pyrazoline compound has a free bond energy (S score) = -10,5357 kcal/mol and the pyrazole compound has a bond free energy (S score) = -9,5256 kcal/mol while the free bond energy for kojic acid as a positive control = -8,8671 kcal/mol. This indicates that the target compounds of pyrazoline and pyrazole are predicted to be potential tyrosinase enzyme inhibitors.
SINTESIS DAN STUDI MOLECULAR DOCKING SENYAWA PIRAZOLIN DAN PIRAZOL TURUNAN 3-BROMO ASETOFENON DAN 3,4- DIMETOKSIBENZALDEHID SEBAGAI INHIBITOR ENZIM TIROSINASE
(perpustakaan UR, 2021-08) Amalia, Widdie; Zamri, Adel
Pyrazoline and pyrazole are heterocyclic compounds containing two nitrogen atoms and possess bioactivity such as tyrosinase inhibitor, antidiabetic and anticancer. Pyrazoline and pyrazole derivatives of 3,4-dimethoxybenzaldehyde and 3-bromoacetophenone were synthesized through one-pot synthesis and followed by an oxidative aromatization reaction. Pyrazoline compound were purified by recrystallization and pyrazole compound were purified using column chromatography. The purity of the target compounds was analyzed by TLC test, melting point measurement and HPLC. The synthesized compounds were then structurally confirmed by UV, FTIR, 1H-NMR and HRMS spectroscopy. The compounds was then tested for its activity as a tyrosinase inhibitor through molecular docking of the tyrosinase crystal structure (PDB ID: 2Y9X). The activity of the target compounds was compared with kojic acid as a positive control. The test results showed that the pyrazoline target compound had a free bond energy (S score) = - 10.2577 kcal/mol while the pyrazole target compound had a free bond energy (S score) = - 10.6895 kcal/mol. When viewed from the positive control, kojic acid has a bond free energy (S score) = -8.4975 kcal/mol, the synthesized pyrazoline and pyrazole compounds have the potential as tyrosinase inhibitor compounds.
SINTESIS DAN UJI AKTIVITAS ANTIBAKTERI KALKON INTI NAFTALEN DARI ASETILNAFTALEN DAN 4-NITROBENZALDEHID
(2016-10-19) Azizah, Nur; Jasril; Zamri, Adel
Chalcon as synthetic compound or natural product had important biology activity. Biology activity of chalcone due to α, β unsaturated system. This research about synthesized a chalcone compound (E)-3-(4-nitrophenil)-1-(naphtalene-1-il)prop-2-en-1-on(AZ1) via aldol condensation reaction by using acetylnaphthalene and 4-nitrobenzaldehyde as precursor. The compound used KOH 6 N as catalyst. AZ had yields 73,02 % and characterized by UV spectroscopy, IR, 1H-NMR and 13C-NMR. The antibacterial activity determined by agar diffusion method in concentration 10 μg/disk and 30 μg/disk. The antibacteria test used Staphylococcus aureus and Bacillus subtilis (Gram positive bacteria), Escherichia coli and Salmonella enteritidis (Gram negative bakteria) as bacteria test
SINTESIS DAN UJI AKTIVITAS ANTIDIABETES SENYAWA ETIL-2- (3-(3-BROMOFENIL)-6-OKSOPIRIDAZIN-1(6H)-IL)ASETAT SECARA IN SILICO DAN IN VITRO
(perpustakaan UR, 2021-07) Oktadini, Dewi; Zamri, Adel
Diabetes mellitus is a chronic disease with impaired carbohydrate, fat and protein metabolism caused by decreased insulin sensitivity and secretion. Pyridazinone is a dinitrogen aromatic ring compound with one carbonyl which has various biological activities, one of which is antidiabetic. This research aims to synthesize pyridazinone derivatives and determine the antidiabetic activity through approaches in silico (molecular docking) and in vitro. The compound ethyl-2-(3-(3-bromophenyl)-6- oxopyridazine-1(6H)-yl)acetate was successfully synthesized using the method stirrer at room temperature from a substitution reaction between the compound 6-(3- bromophenyl)pyridazine-3(2H)-one with ethyl chloroacetate. The purity of the compound was determined by TLC test, melting point measurement and HPLC. The structure of the synthesized compound was confirmed by spectroscopic analysis of UV, FTIR, 1H-NMR and HRMS. The synthesized compounds were tested for antidiabetic activity in silico (molecular docking) and in vitro. Study was molecular docking carried out on the crystal structure of human lysosomal acid-α-glucosidase in complex with moranolin from the database (PDB-ID 5NN5) and in vitro of the enzyme α-glucosidase. The activity of the ethyl-2-(3-(3-bromophenyl)-6-oxopyridazine-1(6H)-yl)acetate was not active as an inhibitor of the α-glucosidase enzyme with IC50 > 2000 μg/mL and confirmed through this study in silico (molecular docking) with binding free energy -11.457 kcal/mol, and only had two hydrogen bond interactions in common with positive control of acarbose, amino acid residues His674 and Arg672.
SINTESIS DAN UJI AKTIVITAS TOKSISITAS SENYAWA ANALOG KALKON TURUNAN 2’-METOKSIASETOFENON
(2016-10-12) Junior, Ronaldo; Zamri, Adel; Eryanti, Yum
Chalcone is one of secondary metabolites from flavonoids group that have been reported to posses many biological activities such as antimicrobial, antitumor, antioxidant, anti-inflammatory, antimalari and anticancer. Chalcone generally can be synthesized by Claisen-Schmidt condensation from aldehide and ketone aromatic using acid or base catalyst. Three hydroxy analogues chalcone i.e., (E)-3-(2-hidroksifenil)-1- (2’-metoksifenil)prop-2-en-1-on, (E)-3-(3-hidroksifenil)-1-(2’-metoksifenil)prop-2-en- 1-on and (E)-3-(4-hidroksifenil)-1-(2’-metoksifenil)prop-2-en-1-on have been synthesized under microwave irradiation by using pottasium hydroxide as catalyst. The structure of those compounds were characterized based on the interpretation of spectroscopic data included UV, FTIR, 1H-NMR and HRMS. Their toxicity activity were determined by using the Brine Shrimp Lethality Test method againts larvae of Artemia salina Leach and showed high activity with LC50 value was 66,59 μg/mL, 107,45 μg/mL and 449,44 μg/mL, respectivel. It indicated that chalcone analogues were potential as anticancer
SINTESIS DAN UJI ANTIBAKTERI SENYAWA (3E,5E)-3,5-BIS (4-HIDROKSIBENZILIDIN)PIPERIDIN-4-ON
(2014-03-27) Sari, Tri Endah Tresna; Eryanti, Yum; Yuharmen; Zamri, Adel
Curcumin is a colouring agent of Curcuma longa L. Beside the use of it as natural colourant, curcumin has biological activities such as antibacterial. In this research, curcumin analog compound of (3E,5E)-3,5-bis(4-hydroxybenzylidene)piperidin-4-one was synthesized with an acid catalyst (SOCl2) and the rendement obtained was 53.49 %. The purity of the compound has been tested using TLC, melting point test, and analytical HPLC. The identification of curcumin analogues was done using UV, IR, MS, 1 H NMR, and 13 C NMR. Antibacterial activity of the compound was identified by using disc diffusion method. The result showed that this analog of curcumin is inactive as an antibacterial agent.
SINTESIS DAN UJI TOKSISITAS (E)-3-(4-((E)-((4-HIDROKSIFENIL) IMINO)METIL)FENIL)-1-(2-METOKSIFENIL)PROP-2-EN-1-ON
(2020-04) Mandalika, Siti Nurfitriani; Zamri, Adel
Chalcone is a compound that has two aromatic rings in its structure and connected by 3 carbon atoms which is an unsaturated α, β carbonyl system. Chalcone conjugated is the conjugation of two bioactive molecules as one of the strategies to obtain new bioactive compounds. Chalcone conjugate (E)-3-(4-((E)-((4-hydroxyphenyl)imino)methyl) phenyl)-1-(2-methoxyphenyl)prop-2-en-1-one was synthesized from (E)-4-(3-(2-methoxy phenyl)-3-oxoprop-1-en-1-yl)benzaldehyde and 4-aminophenol by microwave irradiation method. The purity of the chalcone conjugate was determined by the TLC test, determination of melting point, and HPLC analysis. The structure of the chalcone conjugate was obtained from UV, FTIR, NMR, and HRMS spectroscopic studies. Synthesis of chalcone conjugate in this research was concluded with a yield 33,60%, and the toxicity was determined by the Brine Shrimp Lethality Test (BSLT) method. The value of the LC50 was showed 6,525 μg/mL. From the data above was concluded that chalcone conjugate was toxic.
SINTESIS DAN UJI TOKSISITAS ANALOG PIRAZOLIN (E)-7-(4-METOKSIBENZILIDEN)-3-(4-METOKSIFENIL)-2-FENIL-3, 3a, 4, 5, 6, 7-HEKSAHIDRO-2H-PIRAZOLO [4,3c] PIRIDIN
(2020-04) Harahap, Farida Hannum; Zamri, Adel
Pyrazoline is five ring heterocyclic compounds with two adjacent nitrogen atoms which is known to have diverse biological activities such as antibacterial, antimalarial, antituberkular, anticancer and antioxidant. This study aims to synthesize derivatives of pyrazoline compounds to add variety and increase their bioactivity. Pyrazoline analogue (E)-7-(4 methoxybenzyliden)-3-(4-methoxyphenyl)-2-phenyl-3, 3a, 4, 5, 6, 7-hexahydro-2H-pyrazolo [4,3-c] piridine (FH-NHP-Pi) was synthesized of curcumin 5-bis ((E)-4-methoxybenzyliden) piperidine -4-on and phenylhydrazine using sodium hydroxide as catalyst. Curcumin was prepared by condensing 4-piperidone monohydrate hydrochloride and 4-methoxybenzaldehide using NaOH as catalyst. Pyrozoline FH-NHP-Pi were synthesized via sealed vessel reactor with stirring speed 1000 rpm 80oC yield of 89,29 %. Purity of the compounds were analyzed using TLC, melting point, and HPLC. The structure of synthesized compounds were confirmed by UV, FTIR, NMR and HRMS spectrocopy studies. The toxicity of pyrazoline were evaluated by Brine Shrimp Lethality Test (BSLT) method. The result of the test showed pyrazoline FH-NHP-Pi is considered non-toxic were 217,3 µg/mL.
SINTESIS DAN UJI TOKSISITAS DUA SENYAWA ANALOG KURKUMIN SIMETRIS DARI SIKLOHEKSANON DENGAN TURUNAN METOKSIBENZALDEHID
(2016-10-19) Lestari, Ayu; Eryanti, Yum; Zamri, Adel
Curcumin is one of secondary metabolites included into the class of fenolic’s group, which was known to have biological activity such as anticancer, antioxidant, antidiabetic and anti-inflammatory. In this research, curcumin analog compounds of cyclohexanone and methoxybenzaldehide derivative were synthesized under microwave irradiation with NaOH. The yield obtained from curcumin analog of (2E,6E)-2,6-bis-(2-methoxybenzilidyn)-cyclohexanone (A1) was 43.97%. The purity of the compound has been tested using TLC, melting point and analytical HPLC. The identification of curcumin analog compound was analysed using UV, IR, 1H-NMR and MS. The toxicity test carried out by Brine Shrimps Lethality Test (BSLT) method to Artemia salina Leach larva showed LC50 higher than 200 ppm for the compound A1 with value of 995.40 ppm. The result of toxicity test showed that the compound A1 was not toxic.
SINTESIS DAN UJI TOKSISITAS SENYAWA (E)-7-(2- METOKSIBENZILIDEN)-3-(2-METOKSIFENIL)-2-FENIL-3, 3a, 4, 5, 6, 7- HEKSAHIDRO-2H-PIRAZOLO [4,3c] PIRIDIN
(2021-03) Aditya, Teguh; Zamri, Adel
Pyrazoline is a dihydropyazole derivative which is included in the azole group of compounds with a heterocyclic-5 structure containing 2 nitrogen atoms, has various biological activities such as anticancer, antiinflation, antioxidants, and antimalarials. The purpose of this study was to synthesize the analog compound pyrazoline (E) -7- (2- methoxybenziliden) -3- (2-methoxyphenyl) -2-phenyl-3, 3a, 4, 5, 6, 7-hexahydro-2Hpyrazolo [4,3c] pyridine through the reaction of a pipiridon derivative curcumin analogue with phenylhydrazine using a sodium hydroxide catalyst. Curcumin compounds are obtained from a condensation reaction between 4-piperidone monohydrate hydrochloride and 2-methoxybenzaldehyde with a NaOH as catalyst. The pyrazoline were synthesized via sealed vessel reactor with a stirring speed of 1000 rpm 80oC yield of 53.15%. purity of the compound were analyzed using TLC, HPLC and melting point. Identification of the structure of pyrazoline compounds by UV, FTIR, NMR, and HRMS spectroscopy. The toxicity of pyrazoline compounds was tested by the BSLT method using A. salina. The test results showed that the pyrazoline compound is non-toxic with a value of LC50 = 674.06 μg / mL.
SINTESIS DAN UJI TOKSISITAS SENYAWA KALKON TURUNAN 2’-HIDROKSI ASETOFENON
(2014-03-27) Lelani; Zamri, Adel; Yuharmen
Chalcone is one of secondary metabolites included into the class of flavonoids that are known to have biological activities. Beside that chalcone can be used as an intermediate for synthesizing heterocyclic compounds, such as flavones, flavanols, flavanones, and others that also have biological activities. In this research, the chalcone derivative of 2’- hydroxyasetophenone was synthesized, it was (E)-3-(2-chlorophenyl)-1-(2-hydroxy phenyl)prop-2-en-1-on, by stirrer method using a base catalyst (KOH) at a room temperature. The purity of this compound has been tested using TLC, melting point test, and analytical HPLC. Then, the chalcone was characterized using UV-Vis, IR spectrophotometer, and 1H NMR, 13C NMR and MS spectroscopy. The toxicity test was done by Brine Shrimp Lethality Test (BSLT) method. Accordings to the primary test, this analogue chalcone compound is potential as anticancer which was proven by LC50 values <200 μg/mL
SINTESIS ONE-POT DAN UJI TOKSISITAS SENYAWA 3-(4-KLOROFENIL)-5-(2-METOKSIFENIL)-1-FENIL-4,5-DIHIDRO-PIRAZOL
(2018-03-07) Sarah, Syarifah Siti; Zamri, Adel
Pyrazoline is five ring heterocyclic compounds with two adjacent nitrogen atoms which is known to have diverse biological activities such as antitoxicity, anticancer, antioxidant, antimalarial, antibacterial and antituberculosis. Pyrazoline analogue 3-(4-chlorophenyl)-5-(2-methoxyphenyl)-1-phenyl-4,5-dihydro-pyrazole (PF-4Cl-2OMe) was synthesized by microwave irradiation method using one-pot reaction involving condensation and cyclization reaction of 2-methoxybenzaldehyde, 4-chloroacetophenon and phenylhydrazine. Purity of the PF-4Cl-2OMe compound was checked on TLC test, determination of melting point and HPLC analysis. Pyrazoline compound have been characterized using UV, FTIR, and NMR spectrometers. The yield obtained from the synthesis of PF-4Cl-2OMe compound was 44.85%.The toxicity of pyrazoline were evaluated by Brine Shrimp Lethality Test (BSLT) method. Pyrazoline PF-4Cl-2OMe compound showed non-toxic activity with LC50 = 572.79 μg/mL.
SINTESIS ONE-POT DAN UJI TOKSISITAS SENYAWA PIRAZOLIN 3-(4-BROMOFENIL)-5-(4-METOKSIFENIL)-1-FENIL-4,5-DIHIDRO-PIRAZOL
(2018-03-07) Pinandita, Septia Dwi; Zamri, Adel
Pyrazoline is a 5-membered ring heterocyclic compound which consist of three carbon atoms and two nitrogen atoms in adjacent position. These compounds have diverse biological activities such as antibacterial, antifungal, anticancer, antiinflamatory, antidepressant, and antioxidants due to the N-N bond on the pyrazoline ring. This research was conducted to synthesize 3-(4-bromophenyl)-5-(4-methoxyphenyl)-1-phenyl-4,5-dihydro-pyrazole (PF-4Br-4OMe). Pyrazoline compound (PF-4Br-4OMe) was synthesized using a one-pot three component reaction of 4-methoxybenzaldehyde, 4-bromoacetophenon, and phenylhydrazine using a strong base catalyst of sodium hydroxide (NaOH) by microwave irradiation method. The purity of the compound was investigated by using TLC test, melting point and HPLC analysis. Pyrazoline compound were characterized using UV, FTIR, NMR and HRMS spectroscopy. The result showed that the pyrazoline compound resulting in a yield of 76,76%. Pyrazoline compound was screened through toxicity test using Brine Shrimp Lethality Test (BSLT) method, and the result showed that pyrazoline compound (PF-4Br-4OMe) was not toxic with LC50 was 733,57 μg/mL.

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