SINTESIS DAN UJI TOKSISITAS PIRAZOLIN 5-(4-METOKSIFENIL)-3-(NAFTALEN-2-IL)-N-FENIL -4,5-DIHIDRO-1H-PIRAZOL-1-KARBOTIAMIDA

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dc.contributor.authorPutri, Sofia Rahmawati
dc.contributor.supervisorJasril, Jasril
dc.date.accessioned2023-02-17T08:18:04Z
dc.date.available2023-02-17T08:18:04Z
dc.date.issued2022-11
dc.description.abstractPyrazoline is heterocycles compound that has various biological activities such as anticancer. Pyrazoline 5-(4-methoxyphenyl)-3-(naphthalen-2-yl)-N-phenyl-4,5-dihydro- 1H-pyrazole-1-carbothioamide (PR-2NFT-4FTS) had successfully synthesized by the formation of chalcone 3-(4-methoxyphenyl)-1-(naphthalen-2-yl)-2-propen-1-one by reacting 2-acetylnaphthalene compound with 4-methoxybenzaldehide. Chalcone was reacted with 4-phenilthiosemicarbazide to produce target compound used hydrochloric acid as catalyst. The purity of the compound was determined using TLC, melting point, and HPLC. The structure of synthesized compound was confirmed by ultraviolet (UV) and fourier transform infra-red (FTIR) spectroscopy data analysis. The yield of the synthesis PR-2NFT-4FTS compound was 35.97%. The toxicity of PR-2NFT-4FTS compound was evaluated by brine shrimp lethality test (BSLT) method with shrimp larvae Artemia salina Leach. The result of the test showed PR-2NFT-4FTS compound is not toxic with LC50 > 1000 μg/mL.en_US
dc.description.sponsorshipFakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Riauen_US
dc.identifier.citationPerpustakaanen_US
dc.identifier.otherElfitra
dc.identifier.urihttps://repository.unri.ac.id/handle/123456789/10861
dc.language.isoenen_US
dc.publisherElfitraen_US
dc.subjectpyrazolineen_US
dc.subjectsynthesisen_US
dc.subjecttoxicityen_US
dc.titleSINTESIS DAN UJI TOKSISITAS PIRAZOLIN 5-(4-METOKSIFENIL)-3-(NAFTALEN-2-IL)-N-FENIL -4,5-DIHIDRO-1H-PIRAZOL-1-KARBOTIAMIDAen_US
dc.typeArticleen_US

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