SINTESIS DAN UJI TOKSISITAS PIRAZOLIN 5-(4-METOKSIFENIL)-3-(NAFTALEN-2-IL)-N-FENIL -4,5-DIHIDRO-1H-PIRAZOL-1-KARBOTIAMIDA
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Date
2022-11
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Elfitra
Abstract
Pyrazoline is heterocycles compound that has various biological activities such as
anticancer. Pyrazoline 5-(4-methoxyphenyl)-3-(naphthalen-2-yl)-N-phenyl-4,5-dihydro-
1H-pyrazole-1-carbothioamide (PR-2NFT-4FTS) had successfully synthesized by the
formation of chalcone 3-(4-methoxyphenyl)-1-(naphthalen-2-yl)-2-propen-1-one by
reacting 2-acetylnaphthalene compound with 4-methoxybenzaldehide. Chalcone was
reacted with 4-phenilthiosemicarbazide to produce target compound used hydrochloric
acid as catalyst. The purity of the compound was determined using TLC, melting point,
and HPLC. The structure of synthesized compound was confirmed by ultraviolet (UV)
and fourier transform infra-red (FTIR) spectroscopy data analysis. The yield of the
synthesis PR-2NFT-4FTS compound was 35.97%. The toxicity of PR-2NFT-4FTS
compound was evaluated by brine shrimp lethality test (BSLT) method with shrimp
larvae Artemia salina Leach. The result of the test showed PR-2NFT-4FTS compound
is not toxic with LC50 > 1000 μg/mL.
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Keywords
pyrazoline, synthesis, toxicity
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