SINTESIS DAN UJI TOKSISITAS SENYAWA N'1,N'3-BIS ((E,Z)-2-FLUOROBENZILIDEN)MALONOHIDRAZID
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Date
2021-10
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perpustakaan UR
Abstract
Hydrazone is a versatile of organic compounds with the structure R1C=N-NHR2. Hydrazones
containing an azomethine -NHN=CH- group which is known to possess diverse biological
activities such as anticancer and antitumor. The addition of fluoro substituents to the aromatic
ring has been shown to improve the pharmacological properties of hydrazone compounds.
Novel compound N'1,N'3-bis((E,Z)-2-fluorobenzyliden)malonohydrazide (DB-2F) was
synthesized via condensation reaction of malonohydrazide and 2-fluorobenzaldehyde with
glacial acetic acid as catalyst. Synthesis of the compound used stirring and heating (reflux)
at 50-60oC. The purity of the compound was determined using TLC, melting point, and
HPLC. The structure of synthesized compound was confirmed by UVand FTIR spectroscopy
studies. The yield of the synthesis DB-2F compound was 59.73%. The toxicity of DB-2F
compound was evaluated by Brine Shrimp Lethality Test (BSLT) method with shrimp larvae
Artemia salina Leach. The result of the test showed DB-2F compound is toxic with LC50 =
175.792 μg/mL.
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Keywords
bslt, hydrazone, toxicity