SINTESIS DAN UJI TOKSISITAS SENYAWA ANALOG 3’, 4’-DIMETOKSI KALKON
No Thumbnail Available
Date
2015-03-23
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Chalcones belong to important class of flavonoid compounds. They have also been
reported to have anticancer, antimicrobial, antifungal, antioxidant, and cytotoxic
activities. In this research, an analogous chalcone of (E)-3-(4-clorophenyl)-1-(3’,4’-
dimetoxyphenyl) prop- 2-en-1-on was synthesized using microwave iradiation and
natrium hidroxide as catalyst. The compound showed a good yield, and then was
characterized by UV spectroscopy, IR, 1H-NMR, and Mass Spectroscopy. Its toxicity
has been identified using Brine Shrimp Lethality Test (BSLT) method on Artemia
salina Leach. The result showed that it had a good toxicity activity with
LC50 = 2.24 μg/ mL and potential as anticancer
Description
Keywords
3’, 4’, dimetoxyacetophenone, BSLT, chalcones, toxicity