SINTESIS DAN UJI TOKSISITAS SENYAWA (1-(NAFTALEN-2-IL) ETILIDEN)HIDRAZIN
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Date
2021-03
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Abstract
Hydrazone is an organic compound that has a basic structure (R1R2C=N-NR3R4).
Azomethine (-NHN=CH) is the active group of the hydrazone compound, which makes
this compound has a variety biological activities. In this research, the synthesis of the
hydrazone compound (1-(naphtalene-2-il)ethyliden)hydrazine (IHK-AN2) obtained
from the condensation reaction between 2-acetylnaphtalene and hydrazine hydrate
catalyzed by acetic acid. The compound was synthesized using microwave irradiation
method with 180 watt. The purity of the compound was determined by TLC, melting
point measurement and HPLC analysis. The compound was analyzed by UV and FTIR
spectrophotometer. Synthesis of hydrazone in this research was concluded with a yield
85,86%. The toxicity of the IHK-AN2 compound was evaluated by BSLT method.
LC50 value of the compound was >1000 μg/mL. From the data above was concluded
that the IHK-AN2 compound was not toxic.
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Keywords
BSLT, hydrazone, toxicity