SINTESIS DAN UJI TOKSISITAS SENYAWA 1-(NAFTALEN-1- ILMETILEN)-2-FENILHIDRAZIN
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Date
2020-10
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Abstract
Hydrazone is an organic compound that has a variety of biological activities such as
antioxidant and anticancer. The active group of hydrazone compound the azomethine
group (-NHN=CH-) makes this compound as an important compound in the
development of new drugs. Hence, in this study, the synthesis of hydrazone
1-(naphthalene-1-ylmetilen)-2-phenylhydrazine (IFA-ND1) was obtained from the
condensation reaction between 1-naphthalene and phenylhydrazine catalyzed by acetic
acid. This compound was synthesized compound by microwave irradiation method at
180 Watt. The purity of the compound is determined by using thin layer
chromatography and melting point. The structure of the synthesized compound was
characterized by the spectrum of UV and FTIR. The bioactivity of the IFA-ND1
compound was evaluated with its toxicity properties by BSLT method with a value of
LC50 = 1.455 μg/mL. This suggests that the IFA-ND1 compound is a potential
compound with toxic properties
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azomethine, hydrazone, toxicity