SINTESIS DAN UJI TOKSISITAS ANALOG PIRAZOL 3-(4-KLOROFENIL)-5-(3-METOKSIFENIL)-1-FENIL-PIRAZOL

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dc.contributor.authorArdiansyah, Filo
dc.contributor.supervisorEryanti, Yum
dc.date.accessioned2021-06-17T07:32:43Z
dc.date.available2021-06-17T07:32:43Z
dc.date.issued2020-05
dc.description.abstractPyrazole is secondary metabolites of the alkaloid group with five atom in heterocyclic ring, consist of three carbon atoms and two nitrogen atoms. Pyrazole have various biological activities, such as antimicrobial, anticancer,antimalarial and antipiuretic. This research is implemented to synthesize pyrazole compound 3-(4-chlorophenyl)-5-(3- methoxyphenyl)-1-phenyl-pirazole (TFP-4Cl-3OMe) and toxicity test for the compounds. A pyrazole compound TFP-4Cl-3OMe was synthesized by heating method with reflux. The structure of the compound was identified by UV spectroscopy, FTIR, NMR, and HRMS analyzed. The yield obtained from the synthesis of TFP-4Cl-3OMe compound was 32,4%. Toxicity test of TFP-4Cl-3OMe compound were determined by the BSLT method using shrimp larvae (Artemia salina Leach). LC50 values of compounds TFP-4Cl-3OMe were 78,34 μg/mL /< 200 μg/mL, it can be concluded are toxic and can be further pharmacologically testeden_US
dc.description.sponsorshipFakultas Matematika dan Ilmu Pengetahuan Alam Universitas Riau Kampus Binawidya, Pekanbaru, 28293, Indonesiaen_US
dc.identifier.otherwahyu sari yeni
dc.identifier.urihttps://repository.unri.ac.id/handle/123456789/9979
dc.language.isoenen_US
dc.subjectpyrazolineen_US
dc.subjectpirazoleen_US
dc.subjectrefluxen_US
dc.subjecttoxicityen_US
dc.titleSINTESIS DAN UJI TOKSISITAS ANALOG PIRAZOL 3-(4-KLOROFENIL)-5-(3-METOKSIFENIL)-1-FENIL-PIRAZOLen_US
dc.typeArticleen_US

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