SINTESIS DAN UJI TOKSISITAS ANALOG PIRAZOL 3-(4-KLOROFENIL)-5-(3-METOKSIFENIL)-1-FENIL-PIRAZOL
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Date
2020-05
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Abstract
Pyrazole is secondary metabolites of the alkaloid group with five atom in heterocyclic
ring, consist of three carbon atoms and two nitrogen atoms. Pyrazole have various
biological activities, such as antimicrobial, anticancer,antimalarial and antipiuretic. This
research is implemented to synthesize pyrazole compound 3-(4-chlorophenyl)-5-(3-
methoxyphenyl)-1-phenyl-pirazole (TFP-4Cl-3OMe) and toxicity test for the
compounds. A pyrazole compound TFP-4Cl-3OMe was synthesized by heating method
with reflux. The structure of the compound was identified by UV spectroscopy, FTIR,
NMR, and HRMS analyzed. The yield obtained from the synthesis of TFP-4Cl-3OMe
compound was 32,4%. Toxicity test of TFP-4Cl-3OMe compound were determined by
the BSLT method using shrimp larvae (Artemia salina Leach). LC50 values of compounds
TFP-4Cl-3OMe were 78,34 μg/mL /< 200 μg/mL, it can be concluded are toxic and can
be further pharmacologically tested
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Keywords
pyrazoline, pirazole, reflux, toxicity