SINTESIS SENYAWA PIRAZOLIN 4-(5-(3-METOKSIFENIL)- 1-(4-NITROFENIL)-4,5-DIHIDRO-1H-PIRAZOL-3-IL)FENOL
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Date
2024-01
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Elfitra
Abstract
Pyrazolin is a five-loop heterocyclic compound that has two nitrogen atoms in its ring
and contains one endocyclic double bond. Pyrazoline compound 4-(5-(3-
methoxyphenyl)-1-(4-nitrophenyl)-4,5-dihydro-1H-pyrazole-3-yl)phenol (P3OME-4OH
-4NTR) had been synthesized in three-step of reaction process. The first step of
formation of chalcone compounds uses the microwave irradiation method with a yield
of 54%. The second step of formation of the compound (4-nitrophenyl)hydrazine uses
the heating stirrer method with a yield of 84%. The last stage of formation of P3OME-
4OH-4NTR compound using the heating stirrer method with a yield of 77%. The purity
of the compound P3OME-4OH-4NTR was tested by measuring melting point, TLC and
HPLC analysis and compound structure was confirmed using UV and FTIR
spectroscopic characterization.
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Keywords
Pyrazoline, reaction, spectroscophy
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