SINTESIS SENYAWA 3-(2-(2-MORPHOLINETOXY)PHENYL)-1- (NAPTHALEN-1-YL)PROP-2-EN-1-ONE
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Date
2023-12
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Elfitra
Abstract
Chalcone is a compound consisting of two aromatic rings connected by three carbon
atoms in a unsaturated α, β carbonyl system. The compound 3-(2-(2-
morpholinetoxy)phenyl)-1-(naphthalen-1-yl)prop-2-en-1-one (CLN-1NFT-2OM) was
successfully synthesized through 2 reaction steps. The first step was the formation of
chalcone (3-(2-hydroxyphenyl)-1-(naphthalen-1-yl)prop-2-en-1-one) by microwave
irradiation method for 75 second with a yield of 91,5%. The second step was the
formation of CLN-1NFT-2OM compound by strirring method at 60-70oC for 6 hours
with a yield of 75,8%. The purity of each compound was analyzed through TLC,
measuring the melting points, and HPLC analysis. The structure of the compound was
confirmed through UV, FTIR, and LC-MS spectroscopy characterization.
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Keywords
chalcone, morpholine, spectroscopy
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