Abstract:
Penicillium sp. LBKURCC34 and LBKURCC30 are fungi that have the potential
to produce secondary metabolites that have many activities. This study was
conducted to produce secondary metabolites using co-culture fermentation.
Extraction of secondary metabolites was carried out using ethyl acetate (EtOAc),
butanol (BuOH) and acetone (Ace). Antimicrobial activity test of these three
extracts was conducted using disc diffusion method. Based on the clear zone area
at concentrations of 2000 and 200 μg/disk, the three extracts did not have
antibacterial activity against the four pathogenic microbes. Antifungal test results
at a concentration of 2000 μg/disk these three extracts have antifungal activity
against C. albicans fungi, while at a concentration of 200 μg/disk only EtOAc and
BuOH extracts have antifungal activity.
