Abstract:
Pyrazoline is five-ring heterocyclic compounds composed of three carbon atoms and two
nitrogen atoms that are close together. The aim of this study was to synthesize
naphthalene core pyrazoline compounds with hydroxy and methoxyphenyl groups on the
pyrazoline ring. The compound 5-(2-methoxyphenyl)-3-(2-hydroxynaphthalen-1-yl)-1-
phenyl-4,5-dihydro-1H-pyrazole (PRZ-2OCH3) was synthesized through two reaction
steps. The first step is the reaction of 2-hydroxy-1-acetylnaphthalene and 2-methoxy
benzaldehyde with NaOH 3N catalyst to give the compound 3-(2-methoxyphenyl)-1-(2-
hydroxynaphthalen-1-yl)-2-propen-1-on. Produces a yield of 90.8%. Further, this
chalcone was reacted with phenylhydrazine over a KOH 3N catalyst to give a yield of
72%. The target pyrazoline compounds were tested by TLC, melting point and HPLC
analyses. Compounds were analyzed by UV-Vis spectrophotometer and FTIR
