Abstract:
Pyrazoline is a five-membered heterocyclic compound with three carbon atoms and two
adjacent nitrogen atoms within the ring. Pyrazoline 5-(2-fluorophenyl)-3-(2-hydroxy
naphthalen-1-yl)-1-phenyl-4,5-dihydro-1H-pyrazole (PR-NH2-2F) had successfully
synthesized by using two-steps, the first step of producing chalcone by reacting an
aldehyde and a ketone involves the aldol condensation reaction, then producing
pyrazoline by cyclization reaction between chalcone and phenylhydrazine. Synthesis of
the pyrazoline by using monowave, at a temperature of 800C for 2 hours. The yield of
the synthesis PR-NH2-2F compound was 52,35%. The purity of the compound was
determined using TLC, melting point, and HPLC. The structure of synthesized
compound was confirmed by ultraviolet (UV) and fourier transform infra-red (FTIR)
spectroscopy data analysis.
