Abstract:
Pyrazoline is a dihydropyazole derivative which is included in the azole group of
compounds with a heterocyclic-5 structure containing 2 nitrogen atoms, has various
biological activities such as anticancer, antiinflation, antioxidants, and antimalarials.
The purpose of this study was to synthesize the analog compound pyrazoline (E) -7- (2-
methoxybenziliden) -3- (2-methoxyphenyl) -2-phenyl-3, 3a, 4, 5, 6, 7-hexahydro-2Hpyrazolo
[4,3c] pyridine through the reaction of a pipiridon derivative curcumin
analogue with phenylhydrazine using a sodium hydroxide catalyst. Curcumin
compounds are obtained from a condensation reaction between 4-piperidone
monohydrate hydrochloride and 2-methoxybenzaldehyde with a NaOH as catalyst. The
pyrazoline were synthesized via sealed vessel reactor with a stirring speed of 1000 rpm
80oC yield of 53.15%. purity of the compound were analyzed using TLC, HPLC and
melting point. Identification of the structure of pyrazoline compounds by UV, FTIR,
NMR, and HRMS spectroscopy. The toxicity of pyrazoline compounds was tested by
the BSLT method using A. salina. The test results showed that the pyrazoline
compound is non-toxic with a value of LC50 = 674.06 μg / mL.
