Abstract:
Pyrazoline is a five-loop compound with two heteroatoms that have various biological
activities such as anti-inflammatory, antimicrobial, antidiabetic, antimalarial, anticancer,
and antioxidant. This study aims to synthesize pyrazoline compounds by adding
variations and increasing their biocativity. Pyrazoline analogue (E)-5-benzyl-7-(4-
chlorobenzyliden)-3-(4-chlorophenyl)-2-phenyl-3, 3a, 4, 5, 6, 7-hexahydro-2H-pyrazolo
[4, 3c] pyridine was synthesized of curcumin (3E, 5E)-1-benzyl-3, 5-bis (4-
kolorobenziliden) piperidine-4-on with phenylhydrazine using sodium hydroxide
catalyst in ethanol solvent. Curcumin compounds are obtained from the aldol
condensation reaction between 1-benzyl-4-piperidone and 4-chlorobenzaldehyde using
sodium hydroxide catalyst in ethanol solvent. Pyrazoline compounds were synthesized
usi
The purity of the compound was determined by using TLC and melting point.
Identification of the structure of pyrazoline compounds by spectroscopic analysis of UV
dan FTIR. The yield obtained from the synthesis of pyrazoline compounds was 46%.
The toxicity of pyrazoline compounds was tested by the BSLT method using A. salina.
The test results showed that the pyrazoline compound is non-toxic with a value of
LC50 = 792,14 μg/mL.
