Abstract:
Pyrazole is a 5 ring heterocyclic compound consisting of three carbon atoms and two
nitrogen atoms in adjacent positions. In this study, the pyrazole analogue
5-(3-chlorophenyl)-3-(naphthalen-2-il)-1-phenyl-1H-pyrazole (PZL-2N-3Cl) was
successfully synthesized from pyrazoline 5-(3-chlorophenyl)-3-(naphthalen-2-il)-1-
phenyl-4,5-dihydro-1H-pyrazoline (PF-CN2-3Cl) with glacial acetic acid via oxidative
aromatization reaction using reflux for 24 hours. The purity of the synthesized
compound was determined using TLC and melting point. The structure of the
synthesized compound was confirmed by UV and FTIR spectroscopic analysis. The
yield obtained from the synthesis of the PZL-2N-3Cl compound was 30,12%. The
toxicity test of pyrazole compounds was determined by the BSLT method using shrimp
larvae (Artemia salina Leach). Pirazol PZL-2N-3Cl is non-toxic with an LC50 value of =
4.634,4 μg / mL
