Browsing by Author "Jasril"

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    AKTIVITAS TOKSISITAS DAN ANTIBAKTERI METABOLIT SEKUNDER EKSTRAK ETIL ASETAT DAGING BIJI TUMBUHAN KLUWAK (Pangium edule Reinw)
    (2016-05-10) Ismar, Rani; Teruna, Hilwan Yuda; Jasril
    Kluwak (Pangium edule Reinw) is a plant that has a lot of potential but has not been widely studied. Kluwak seeds consist 33.16% methyl linoleate and 44.93% methyl oleate that can be used as source of essential oil. The extraction of kluwak oil was carried out by maceration using ethyl acetate because the extraction’s temperature was below the solvent’s boiling point so that the degradation of oil component as the effect of heat can be avoided. Our finding showed that 12.03% kluwak oil consist 4.68% patchouli alcohol; 12.26% methyl palmitate; 33.16% methyl linoleate; 44.93% methyl oleate and 4.97% methyl stearate. Toxicity activity assay using BSLT method showed that kluwak oil was not toxic againts Artemia salina with LC50 values more than 1000 ppm. The antibacterial activity determined by agar diffusion method in concentration of 30; 60; 90 and 150 𝜇𝜇g/disk. Bacteria that have been used for this evaluation were Escherichia coli and Bacillus subtilis. This antibacterial assay indicated that the kluwak oil has activity against both bacterial tested.
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    Bahan Alam Organik Sebagai Sumber Obat Moderen
    (2015-01-22) Jasril
    Umat manusia dalam kehidupannya sangat bergantung kepada bahan-bahan organik alami yang dapat diperoleh dari lingkungan sekitarnya, baik yang berasal dari tumbuh-tumbuhan, hewan, maupun mikroorganisme. Penggunaan bahan-bahan organik alami untuk memenuhi berbagai keperluan umat manusia, seperti sandang, pangan, papan, energi, pewama, parfum, komestik, insektisida, dan obat-obatan telah mempengaruhi dan memberi ciri tersendiri kepada peradaban mereka. Sebagai obat-obatan, bahan organik alami telah sejak lama diketahui sebagai sumber yang potensial, baik yang digunakan secara tradisionil maupun moderen untuk menyembuhkan berbagai penyakit
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    Bahan Alam Organik Sebagai Sumber Obat Moderen
    (2012-11-11) Jasril
    Sel organisme makhluk hidup baik yang hidup di darat maupun yang hidup di laut merupakan tempat aktivitas sintesis yang rumit dan kompleks, dimana dihasilkan senyawa-senyawa organik dengan keanekaragaman struktur molekul dan aktivitas biologi yang bermanfaat bagi kesejahteraan hidup manusia. Senyawa organik yang berasal dari sumber alam hayati terdiri dari 2 kelompok senyawa berdasarkan proses metabolismenya yaitu metabolit primer dan metabolit sekunder. Metabolit sekunder ini kemudian lebih dikenal dengan senyawa organik bahan alam (natural products). Kehadiran metabolit sekunder telah memberikan ciri khas tersendiri bagi organisme yang menghasilkannya. Biosintesis metabolit sekunder berasal dari metabolit primer yang dimulai dari proses fotosintesis yang membentuk glukosa. Selanjutnya glikolisis dari glukosa akan menghasilkan posfoenol piruvat, yang berikutnya akan menghasilkan asam shikimat dan asetil koenzim-A (menurunkan asam mevalonat dan asam malonat), yang pada akhirnya akan menghasilkan beragam bentuk struktur molekul senyawa metabolit sekunder. Metabolit sekunder dapat digolongkan kedalam beberapa kelompok berdasarkan struktur molekul dan komposisinya, diantaranya yaitu: terpenoid, steroid, flavonoid, alkaloid, kumarin, kuinon, dan lignan.
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    ISOLASI DAN UJI TOKSISITAS METABOLIT SEKUNDER EKSTRAK n-HEKSANA KULIT BATANG TUMBUHAN Polyalthia pulchra var. angustifolia King (ANNONACEAE)
    (2014-03-27) Yuhendri; Jasril; Yuharmen
    The secondary metabolites of the stem bark of Polyalthia pulchra were isolated and than their toxicity activity assayed using Brine Shrimp Lethality Test (BSLT) method. The sample was extracted by maceration method using n-hexane solvent. Structures of the isolated compounds were conducted using Gas Chromatography and Mass Spectrometry (GC-MS). The dried sample produced 3.21 g n-hexane extract (0.25%) and 0.032 g 2nd fraction of n-hexane (FH2) (0.0025%). The toxicity assay showed that n-hexane extract and FH2 fraction was toxic with LC50 5.9 and 7.1 ppm. From the results of GC–MS analysis, it is shown that FH2 fraction contains campesterol, stigmasterol, and γ-sitosterol compounds with retention times 75.605, 76.568 and, 78.172 minutes, respectively.
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    ISOLASI DAN UJI TOKSISITAS SENYAWA METABOLIT SEKUNDER EKSTRAK METANOL DARI DAGING BIJI TUMBUHAN Pangium edule REINW (FLACOURTIACEAE)
    (2016-05-02) Anggara, Yudi; Teruna, Hilwan Yuda; Jasril
    Pangium edule is a plant that found in Taluk Kuantan Riau Province. This plant has potential as a source of flavonoids. Seed flesh (endorsperm) was extracted using methanol and separated by column chromatography, and produced several fractions. One of fraction (F6) was characterized using UV-Vis and FT-IR spectroscopy. Based on the spectra, this fraction showed a characteristic of flavonoid. Toxicity tests were, conducted on the extracts and fractions with BSLT method. Toxicity test results showed that the methanol extracts has the LC50 higher than 1000 ppm and the fraction has the LC50 718,3 ppm. It can be concluded that the methanol extracted was not toxic and a F6 was toxic.
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    Isolasi Metabolit Sekunder Buah Tumbuhan Tabernaemontana Sphaerocarpa (Apocynaceae)
    (2013-02-27) Eryanti, Yum; Jasril
    Telah dilakukan penelitian tentang isolasi metabolit seknnder buah tumbuhan Tabernaemontana sphaerocarpa (Apocynaceae). Padatan senyawa yang diperoleh diberi nama TSl yang mempunyai Rf = 0.57 (etil asetat: metanol + 1 tetes amonia = 7:3), Rf = 0.66 (B:A:W = 4:1:5). Hasil karakterisasi UV memberikan dua puncak serapan masing-masing pada panjang gelombang 245 ran (A = 1.784) dan 274.8 nm (A = 0.875) menunjukkan adanya sistem ikatan TI terkonjugasi dan senyawa TSl juga mengandung cincin aromatik. Spektrum IR menunjukkan adanya pita serapan pada billangan gelombang 3260 cm'' (N-CK3) atau (-OH), serapan 2953 cm' untuk ulur C-H aromatik, 1587 cm' menunjukkan adanya ikatan rangkap C=C. Spektrum ' H - NMR menunjiikkan adanya II dari cincin aromatis pada pergeseran kimia 5 sekitar 6.4-7.7 ppm, H dari C=C pada pergeseran kimia 6 = 4.29 ppm, H dari metil dan metilen pada pergeseran kimia 6 = 1.28-1.79 ppm dan H dari N-CH3 pada pergeseran kimia 8 2.01-1.79 ppm.
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    ISOLASI MINYAK ATSIRI DARI BATANG Alpinia malaccensis Roxb DENGAN HIDRODISTILASI KONVENSIONAL DAN MICROWAVE SERTA UJI AKTIVITAS ANTIMIKROBA
    (2017-01-24) Cahyani, Anita; Yuharmen; Jasril
    Alpinia malaccensis plants was one of essential oil source which has antimicrobial activity. Isolation of essential oil from Alpinia malaccensis was carried out with traditional hydrodistillation method and microwave method. Optimal conditions in the traditional method was 6 hours, while the optimal conditions in the microwave method were 100 oC, 600 W, and 90 minutes. Isolation of the essential oil from Alpinia malaccensis with traditional method produces higher yield (0.009%) compared to microwave method (0.002%). Compounds in the essential oil of Alpinia malaccensis stem identified by GC-MS. The main component of essential oil rod Alpinia malaccensis obtained by using hydrodistillation and microwave-assisted hydrodistillation is methyl cinnamic as much as 98.24% and 96.97% respectively. Essential oils rod hydrodistillation of Alpinia malaccensis from traditional hydrodistillation method and hydrodistillation microwave method was active as an antimicrobial agent.
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    SINTESIS (E)-1-NAFTALEN-1-IL-3-(3-NITRO-FENIL)-PROPENON DARI 1-ASETILNAFTALEN DAN 3-NITROBENZALDEHID
    (2014-03-27) Andriyani, N. C.; Balatif, N.; Jasril
    Chalcone of (E)-1-naphthalene-1-yl-3-(3-nitro-phenyl)-propenone has been synthesized by aldol condensation using NaOH as a catalyst. The synthesis of chalcone compound used stirring method by reacting 1-acetylnaphthalene with 3-nitrobenzaldehyde. (E)-1-naphthalene-1-yl-3-(3-nitro-phenyl)-propenone compound obtained has a good yield 88,68 %. The compound has been characterized using UV, FTIR, NMR and Mass spectroscopy. Data characterization showed that the compound obtained was target compound.
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    SINTESIS (E)-3-(3-BROMOFENIL)-1-(NAFTALEN-2-IL)PROP-2-EN-2-ON DARI 2-ASETILNAFTALEN DAN 3-BROMOBENZALDEHID
    (2014-03-27) Muttakin, I.; Balatif, N.; Jasril
    Chalcone of (E)-3-(3-bromophenil)-1-(naphtalen-2-yl)prop-2-en-2-one has been synthesized from 2- acethylnapthalene and 3- bromobenzaldehyd by aldol condensation using the stirring method with base catalyst (NaOH). The yield obtained for this compound was 61.21 %. The purity of product has been evaluated using TLC, melting point test, and HPLC analysis. The structure of the synthesized compound was confirmed by UV UV, FTIR, NMR, and MS analysis. Data characterization showed that the compound obtained was the targeted compound
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    SINTESIS (E)-3-(3-KLOROFENIL)-1-(NAFTALEN-1-IL) PROP-2-EN-1-ON DARI 1-ASETILNAFTALEN DAN 3-KLOROBENZALDEHID MELALUI KONDENSASI ALDOL
    (2014-03-27) Anisah; Balatif, N.; Jasril
    Chalcone (E)-3-(3-chlorophenyl)-1-(naphthalen-1-yl)prop-2-en-1-one was synthesized by aldol condensation reaction from 1-acetylnaphthalen with 3-chlorobenzaldehyde using NaOH catalyst by stirring method. (E)-3-(3-chlorophenyl)-1-(naphthalen-1- yl)prop-2-en-1-one compound obtained in yield 87,81 %. The structures of synthesized compounds were well characterized by UV, IR, NMR, and Mass spectroscopy showed that the compound obtained was correlated to our target compound
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    SINTESIS (E)-3-(4-FLUOROFENIL)-1-(NAFTALEN-1-IL)PROP-2-EN-1-ON DARI 1-ASETILNAFTALEN DAN 4-FLUOROBENZALDEHID
    (2014-03-27) Fitria, D.; Teruna, H. Y.; Jasril
    Chalcone analogues has been synthesized by aldol condensation using stirring method with a base catalyst (KOH). Starting material that has been used was 1- acetylnaphthalene as ketone and 4-fluorobenzaldehyde as aldehyde. This compound were (E)-3-(4-flurophenyl)-1-(naphthalen-1-yl)prop-2-en-1-one. The purity of the product has been evaluated by TLC, melting point test, and HPLC analysis. The structures of the synthesized compound were confirmed by UV, FTIR, NMR, and MS analysis. Data of characterization showed that the compound obtained was based on target compound
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    SINTESIS (E)-3-(4-HIDROKSIFENIL)-1-(NAFTALEN-1-IL)PROP-2-EN-1-ON DARI ASETILNAFTALEN DAN 4-HIDROKSIBENZALDEHID
    (2014-03-27) Putri, R. E.; Zamri, A.; Jasril
    Chalcone of (E) 3 (4 hydroxyfenil) 1 (naphthalene 1 il)prop 2 en 1 on has been synthesized from 1 acetylnaphthalene with 4 hydroxybenzaldehyde by microwave irradiation method with potassium hydroxide catalyst at room temperature. The yield of synthesized compound was 68.26% and characterized by using UV, IR, NMR and Mass spectroscopy. Data of characterization showed that compound that have been obtained was based on target compound
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    SINTESIS 3-(4-BROMOFENIL)-1-(NAFTALEN-1-IL)PROP-2-EN-1-ON DARI 1-ASETILNAFTALEN DENGAN 4-BROMOBENZALDEHID
    (2014-03-27) Sari, R. I. P; Yuharmen; Jasril
    Chalcone of 3-(4-Bromo-phenyl)-1-naphthalen-1-yl-propenone was synthesized by the stirring method in Claisen-Schmidt Condensation with NaOH asthecatalyst.The structure of the compound was confirmed by 1H-NMR,13 C-NMR, IR, MS, and UV spectroscopy method. The compound produced was in 81.9% yields. Data characterization showed that the compound obtained was the target ted compoud
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    SINTESIS ANALOG KALKON TURUNAN 3’-HIDROKSIASETOFENON DAN METOKSIBENZALDEHID MENGGUNAKAN METODE IRADIASI MICROWAVE
    (2016-10-19) Nurhalis, Mukhsin; Jasril; Zamri, Adel
    Chalcone (E)-1-(3’-hidroxyphenyl)-3-(3-methoxysiphenyl)prop-2-en-1-one (MN) have been synthesized by Claisen–Schmidt condensation using potassium hydroxide as a catalyst under microwave irradiation. The reactions took placed in a short time (4 minutes) with a satisfying yield (55-96%). The chalcone structure was characterized based on the interpretation of spectroscopic data included UV, FTIR, 1H NMR and HRMS.
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    SINTESIS ANALOG KURKUMIN TURUNAN 1-BENZIL 4-PIPERIDINON MENGGUNAKAN KATALIS BASA DAN UJI AKTIVITAS SEBAGAI ANTIBAKTERI
    (2014-03-27) Wahyuni, S.; Eryanti, Y.; Zamri, A.; Jasril
    Curcumin is one of secondary metabolites with phenolic group which was known to have various biological activities such as antimicroba, anticancer, antioxidant, antitumor and anti-inflammatory activities. In this research, curcumin analog of 1-benzil-4- piperidone derivative was synthesized using microwave irradiation with catalyst NaOH. The rendement (YN2) resulted 99.39%. All compounds were characterized using UV spectrophotometer, IR spectrophotometer, 1 H NMR, and 13 C NMR spectrometers. The antibacterial activity was evaluated using the agar diffusion method. Antibacterial activity test was carried out at concentrations of 20, 30, 40, 50 , and 60 mg/disc against Gram positive bacteria (Staphylococcus aureus and Bacillus subtilis) and Gram negative bacteria (Escherichia coli and Salmonella enteritidis). YN 2 compounds obtained showed different antibacterial activity against different bacteria.
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    SINTESIS ANALOG PIRAZOLIN 5-(4-FLOROFENIL)-3-(NAFTALEN-1-IL)-1-FENIL-4,5-DIHIDRO-1H-PIRAZOL
    (2016-05-02) Yones, Agus; Balatif, Nur; Jasril
    Pyrazoline analog compound, 5-(4-florophenyl)-3-(naphthalen-1-yl)-1-phenyl-4,5-dihydro-1H-pyrazole (PF CN1-4F) has been synthesized through cyclization reaction between chalcone analog compound (E)-3-(4-florophenyl)-1-naphtalen-1-yl-propenone (CN1-4F) and phenylhidrazine using acetic acid glacial as catalyst with microwave. The purity of the compound was identified by TLC, and HPLC. Its structure was characterized using spectroscopy UV, IR, and MS. The pyrazoline analog compound was yellow crystals with a yield of 50.52%. Characterization result showed that it was our targetted compound.
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    Sintesis Calkon Piridin Bervariasi Gugus Fungsi Sebagai Antibakteri dan Inhibitor Asetilkolinesterase
    (2012-10-28) Jasril
    Calkon merupakan salah satu golongan senyawa bahan alam dari jenis flavonoid yang banyak ditemukan pada berbagai spesies tumbuhan. Senyawasenyawa calkon juga dikenal memiliki berbagai aktivitas biologi yang menarik, antara lain sebagai antioksidan, antitumor, antiinflamasi, antimikroba dan lain-lain. Kandungan calkon pada berbagai ekstrak tumbuhan sangat bervariasi, tetapi pada umumnya sangat rendah. Hal ini mungkin disebabkan calkon merupakan produk antara dalam proses biosintesis pembentukan senyawa-senyawa flavonoid lain. Hal ini merupakan salah satu pendorong bagi kami untuk mengembangkan atau merekayasa molekul calkon baik untuk mempelajari sifat fisiko-kimianya, mempelajarai kaitan antara struktur dan aktivitasnya, serta yang tidak kalah penting tentunya adalah sebagai salah satu usaha dalam menemukan obat-obat baru yang lebih potensial. Sintesis senyawa turunan calkon dapat dilakukan dalam satu tahap reaksi melalui kondensasi aldol dengan menggunakan reaktan senyawa aldehid aromatik dan keton aromatik. Pada penelitian ini akan dilakukan sintesis senyawa calkon piridin dengan kehadiran berbagai gugus fungsi seperti halogen (F, Cl dan Br), nitro, hidroksi dan amina. Pada penelitian ini juga akan dilakukan sintesis calkon dengan kombinasi inti piridin dan dan beberapa inti heterosiklis lainnya
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    Sintesis Calkon Piridin dan Turunannya dari 2-Asetilpiridin dengan Metoksibenzaldehid serta Uji Aktivitasnya sebagai Antioksidan
    (2013-03-08) Oktari, S.; Hendra, R.; Jasril
    Chalcone are known to exhibit various biological activities such as antioxidant, antimalaria, anticancer, anti-inflammatory and antimicrobial. Chalcone as antioxidant can neutralize free radicals by donating an electron to the reactive species. Two analogous chalcone have been synthesized from 2-acetyl pyridine and methoxybenzaldehyd derivates with claisen schmidt condensation using base catalyst KOH. The compounds of synthesized produce are 2,6-bis(3,4-dimethoxyphenyl)- 4-hydroxy-4-(pyridine-2-yl)cyclohexane- 1,3-diil)bis(pyridine-2-ilmetanon) (SC1) and (E)-3-(2,4,5-trimethoxy phenyl) -1-(pyridine-2-yl) prop-2-en-1-one (SC2). The productc of synthesis then characterized using UV, IR, 1H-NMR, 13C-NMR and mass spectroscopy. Antioxidant activity was tested using DPPH method and the standard used is ascorbic acid. Assay results of the two compounds showed very weak antioxidant activity because the IC50 is more than 250 ppm
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    SINTESIS DAN KARAKTERISASI SENYAWA (E)-3-(2-BROMOFENIL)-1-(NAFTALENIL)-2- PROPENON
    (2016-05-10) Safitri, Ariesta; Jasril; Eryanti, Yum
    A chalcone (E)-3-(2-Bromo fenil)-1-(Naftalenil)-2- Propenon were synthesized by Claisen–Schmidt condensation of 1-acetilnaphthalene with 2-bromobenzaldehyde using NaOH as catalyst. Its structures of compound were characterized based on the interpretation of spectroscopic data including UV, FTIR, NMR, and MS. The compound show a good yield (60,57%). Its melting point observed in the range of 102-103 0 C.
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    SINTESIS DAN KARAKTERISASI SENYAWA ANALOG PIRAZOLIN 5-(2-BROMOFENIL)-3-(NAFTALEN-2-IL)-1-FENIL-4,5-DIHIDRO-1H-PIRAZOL
    (2016-05-16) Lestari, Santy; Eryanti, Yum; Jasril
    Pyrazoline analog compound, 5-(2-bromophenyl)-3-(naphthalen-2-yl)-1-phenyl-4,5-dihydro-1H-pyrazole (PF CN2-2Br) has been synthesized through cyclization reaction between chalcone analog compounds and phenylhidrazine using acetic acid glacial as catalyst with microwave. A compound of chalcone analog, (E)-3-(2-bromophenyl)-1-(naphthalen-2-yl)prop-2-en-1-one (CN2-2Br) has been synthesized through Claisen-Schmidt reaction using irradiation microwave from 2-acetylnaphtalene and 2-bromobenzaldehyde using NaOH 1N as catalyst. PF CN2-2Br compounds structure was characterized using spectroscopy UV, IR and MS and it’s showed a good yield. PF CN2-2Br compound yields was 60,39%.