ISOLASI DAN UJI AKTIVITAS ANTIJAMUR SENYAWA METABOLIT SEKUNDER DARI EKSTRAK METANOL KULIT BATANG Goniothalamus sp. (ANNONACEAE)
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Date
2016-05-02
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Abstract
The aim of this study was to isolate the secondary metabolites of the stem bark of
Gonoiothalamus sp. and to determine antifungal activity of methanol extract. The
methanol extract was fractionated using column chromatography. One of the fractions
was recrystallized and found as was yellowish crystals (F4). Its HPLC chromatogram
compared with HPLC chromatogram of pinocembrin. The result showed that he
yellowish crystals (F4) was pinocembrin. Antifungal assay was conducted by the agar
diffusion method against Candida albicans and Aspergillus niger. The methanol extract
and F4 exhibited weak activity against Candida albicans with inhibition zone 9.03 mm
for methanol extract and 8.50 mm for F4, while methanol extract and F4 was inactive
againts Aspergillus niger.
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Keywords
Gonoiothalamus sp, pinocembrin, antifungal activity