SINTESIS DAN UJI TOKSISITAS SENYAWA 5-(4-FLUOROFENIL)-3-(1-HIDROKSINAFTALEN-2-IL)-1-FENIL-4,5-DIHIDRO-1HPIRAZOL

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dc.contributor.authorNadia, Airin
dc.contributor.supervisorJasril, Jasril
dc.date.accessioned2022-03-15T01:56:19Z
dc.date.available2022-03-15T01:56:19Z
dc.date.issued2021-10
dc.description.abstractPyrazoline is a five ring heterocyclic compounds that cointaining two nitrogen atoms in a close position with one double bond in the ring which is known to have various bioactivities such as an anti-oxidant, anti-cancer, anti-microbial, and anti-bacterial. The pyrazoline derivative 5-(4- fluoropheny)-3-(1-hydroxynaphthalene-2-yl)-1-phenyl-4,5-dihydro-1H-pyrazole (PF-NH1-4F) was synthesized by the cyclization reaction of chalcone 3-(4-fluorophenyl)-1-(1- hydroxynaphthalene-2-yl)-2-propen-1-one and phenyl hydrazine with NaOH (in methanol) as catalyst using monowave at 80°C for an hour. The chalcone was prepared by condensing 1- hydroxy-2-acetylnaphtalene and 4-fluorobenzaldehyde with NaOH as catalyst using microwave irradiation at 180 W about 17 minutes. The purity of the pyrazoline was analyzed using TLC, melting point, and HPLC. The yield of the synthesis of chalcone and pyrazoline compounds was 45% and 27,3%. The structure of the synthesized pyrazoline was comfirmed by UV, FTIR, and HRMS spectroscopy analysis. The toxicity of pyrazoline was evaluated by Brine Shrimp Lethality Test (BSLT) method. The result of the test showed that the pyrazoline PF-NH1-4F is highly toxic with LC50 value was 11,1 μg/mLen_US
dc.description.sponsorshipDosen Bidang Kimia Organik Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Riauen_US
dc.identifier.otherwahyu sari yeni
dc.identifier.urihttps://repository.unri.ac.id/handle/123456789/10477
dc.language.isoenen_US
dc.publisherperpustakaan URen_US
dc.subjectBSLTen_US
dc.subjectchalconeen_US
dc.subjectpyrazolineen_US
dc.titleSINTESIS DAN UJI TOKSISITAS SENYAWA 5-(4-FLUOROFENIL)-3-(1-HIDROKSINAFTALEN-2-IL)-1-FENIL-4,5-DIHIDRO-1HPIRAZOLen_US
dc.typeArticleen_US

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