SINTESIS DAN UJI TOKSISITAS SENYAWA METOKSI FLAVANON TURUNAN 2’-HIDROKSIKALKON

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dc.contributor.authorRizal, Syamsul
dc.date.accessioned2015-03-31T04:19:16Z
dc.date.available2015-03-31T04:19:16Z
dc.date.issued2015-03-31
dc.description.abstractFlavanone is one of secondary metabolities included into flavonoid group that has biological activities such as anticancer, antitumor, antiproliferative, and antimicrobe. Moreover, flavanone is the biosynthesis main precursor for other types of flavonoids. In this research, 4’-methoxyflavanone has been synthesized from cyclization of 2’- hydroxychalcones derivatives by microwave irradiation using sodium acetate in ethanol and water as a catalyst. The yield obtained was 68,5 %. The purity of compound has been tested using TLC, melting point test, and HPLC. The compound was characterized by UV, IR, 1H-NMR, and MS. Toxicity activity was determined using Brine Shrimp Lethality Test (BSLT) against larvae of Arthemia salina Leach and with value LC50 = 3,29 μg/mL. Accordings to the primary test, the flavanone compound is potentially as anticancer which was proven by LC50 values <200 μg/mL.en_US
dc.description.sponsorshipYuharmen, Adel Zamrien_US
dc.identifier.otherwahyu sari yeni
dc.identifier.urihttp://repository.unri.ac.id/xmlui/handle/123456789/6893
dc.language.isoenen_US
dc.subject2’-hydroxychalconeen_US
dc.subjectBrine Shrimp Lethality Test (BSLT)en_US
dc.subjectflavanoneen_US
dc.subjectmicrowave irradiationen_US
dc.subjecttoxicityen_US
dc.titleSINTESIS DAN UJI TOKSISITAS SENYAWA METOKSI FLAVANON TURUNAN 2’-HIDROKSIKALKONen_US
dc.typeUR-Student Paper Diplomaen_US

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