AKTIVITAS ANTIDEPRESAN EKSTRAK n-HEKSANA BIJI PINANG TUA DENGAN METODA FORCED SWIM TEST PADA MENCIT JANTAN (Mus musculus)
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Date
2023-12
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Elfitra
Abstract
Depression is a mental health disorder characterized by unstable mood and frequent
emotional changes. Antidepressant drugs can be used as initial pharmacological
therapy for depressive disorders. The Forced Swim Test (FST) method is a method
used to see antidepressant activity. This study aims to determine the antidepressant
activity of n-hexane extract of mature areca nut seeds using the FST method acutely.
FST was used because it is one of the most widely used in vivo methods for
detecting antidepressant drugs in test animals. The injection into mice was carried
out intraperitoneally 1 hour before FST at a dose of 10 mg/kg and the control group
was only injected with 0.9% saline. N-hexane extract of old areca nut seeds at a
dose of 10 mg/kg was not effective as an antidepressant because there was no
significant reduction in immobility time compared to controls.
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Keywords
antidepressant, forced swim test, in vivo
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