Diabetes Melitus
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Date
2013-04-18
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Abstract
Diabetes mellitus is one of a metabolism disorder with characteristic of the
hyperglycemia caused by abnormal insulin secretion resistance, insulin metabolism, or both.
Diabetes mellitus with hyperglycemia cause increasing oxidative stress and distrubance
antioxidant defence. Pandanus conoideus Lam. oil containing ^-carotene, p-cryptoxanthin and
a-tocopherol can reduce oxidative stress. This study aimed to determine the effect of
glibenclamide combination P. conoideus Lam. oil on uric acid serum. Wistar rats were divided
into four groups; normal group, DM group, diabetic group given glibenclamide and diabetic
groups were given glihenclamide combination Pandanus conoideus Lam. oil The results showed
significant differences (p <0.05) on uric acid serum. Based on this study; it can be concluded
that administration of glibenclamide combination Pandanus conoideus Lam. oil can decrease
uric acid average in diabetic rats.
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Keywords
Pandanus conoideus Lam, oil, diabetes mellitus, hyperglicemia, antioxidant, uric acid