ISOLASI DAN UJI AKTIVITAS PENGHAMBATAN α-GLUKOSIDASE SENYAWA METABOLIT SEKUNDER EKSTRAK n-HEKSANA DARI DAUN NONA MAKAN SIRIH (Clerodendrum thomsoniae Balf.f.)

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dc.contributor.authorAbelsia, Anggun Ratu
dc.contributor.supervisorTeruna, Hilwan Yuda
dc.date.accessioned2022-10-26T04:24:12Z
dc.date.available2022-10-26T04:24:12Z
dc.date.issued2022-07
dc.description.abstractClerodendrum thomsoniae is a species of the Lamiaceae family which is used as a medicinal plant. Previous studies on several species of the genus Clerodendrum has shown that this genus has secondary metabolites that have the potential to be antidiabetic, antioxidant, anti-inflammatory, anticancer, and antiasma agents. This study aims to isolate secondary metabolite compounds from the leaves of C. thomsoniae and test the inhibitory activity of the enzyme α-glucosidase. Isolation of the plants leaves has been carried out by the maceration method using methanol solvent and partioned with n-hexane. The metabolites of n-hexane fraction have been separated using the vacuum liquid chromatography method. Fraction 4 of VLC has been re-separated by the flash chromatography method and obtained 93 vials. Purification of the compound was carried out on vials 21-22 and white crystalline solids (10.75 mg) were obtained. Characterization of the compound was carried out by FTIR spectroscopy which showed the presence of OH, aliphatic C-H, CH2, CH3, C=C alkenes cyclic and C-O (alcohol) groups. The melting point of the compound in the range of 140-142°C. The TLC profile of CT-H-V4-FL21 was not similar to β-sitosterol, therefore these two compounds were different. The enzyme inhibition test of α-glucosidase showed this compound had a weak inhibitory activity with an inhibition percentage of 6.60%.en_US
dc.description.sponsorshipFakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Riauen_US
dc.identifier.citationPerpustakaanen_US
dc.identifier.otherElfitra
dc.identifier.urihttps://repository.unri.ac.id/handle/123456789/10721
dc.language.isoenen_US
dc.publisherElfitraen_US
dc.subjectClerodendrum thomsoniaeen_US
dc.subjectinhibitionen_US
dc.subjectisolationen_US
dc.titleISOLASI DAN UJI AKTIVITAS PENGHAMBATAN α-GLUKOSIDASE SENYAWA METABOLIT SEKUNDER EKSTRAK n-HEKSANA DARI DAUN NONA MAKAN SIRIH (Clerodendrum thomsoniae Balf.f.)en_US
dc.typeArticleen_US

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