SINTESIS DAN UJI TOKSISITAS PIRAZOLIN 4-(3-(4-FLOROFENIL)-5- (2-METOKSIFENIL)-4-5-DIHIDRO-1H-PIRAZOL-1- IL)BENZENASULFONAMIDA SEBAGAI INHIBITOR ENZIM TIROSINASE
dc.contributor.author | Hidayat, Rohim | |
dc.contributor.supervisor | Eryanty, Yum | |
dc.date.accessioned | 2023-03-14T03:16:35Z | |
dc.date.available | 2023-03-14T03:16:35Z | |
dc.date.issued | 2022-12 | |
dc.description.abstract | Pyrazoline is a five-ring heterocyclic compound containing two nitrogen atoms in the ring. Pyrazoline had a wide variety of biological activities, such as an inhibitor of the tyrosinase enzyme. Pyrazoline 4-(3-(4-florophenyl)-5-(2-methoxyphenyl)-4-5-dihydro- 1H-pyrazole-1-yl)benzenesulfonamide has been successfully synthesized through various stages. The first step is the formation of chalcone compounds by reacting 4- floroacetophenone and 2-methoxybenzaldehyde through the Claisen-Schmidt reaction using microwave irradiation. Then it is reacted with 4-hydrazinylbenzenesulfonamide which is synthesized through azotation and further reduction reactions, then the cyclization reaction between chalcone and 4-hydrazinylbenzensulfonamide by reflux method for 9 hours at 80°C. The structure of the synthesized compounds was confirmed by characterization using ultraviolet (UV) spectroscopy, fourier transform infra red (FTIR) and high-resolution mass spectroscopy (HRMS). The yield obtained from this pyrazoline synthesis was 93%. The toxicity of pyrazoline compounds was tested using the Brine Shrimp Lethality Test (BSLT) method using Artemia salina leach. The pyrazoline compound obtained was non-toxic with an LC50 value of 3,706 μg/mL. | en_US |
dc.description.sponsorship | Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Riau | en_US |
dc.identifier.citation | Perpustakaan | en_US |
dc.identifier.other | Elfitra | |
dc.identifier.uri | https://repository.unri.ac.id/handle/123456789/10900 | |
dc.language.iso | en | en_US |
dc.publisher | Elfitra | en_US |
dc.subject | Brine Shrimp Lethality Test | en_US |
dc.subject | pyrazoline | en_US |
dc.subject | toxicity test | en_US |
dc.title | SINTESIS DAN UJI TOKSISITAS PIRAZOLIN 4-(3-(4-FLOROFENIL)-5- (2-METOKSIFENIL)-4-5-DIHIDRO-1H-PIRAZOL-1- IL)BENZENASULFONAMIDA SEBAGAI INHIBITOR ENZIM TIROSINASE | en_US |
dc.type | Article | en_US |
Files
Original bundle
1 - 1 of 1
No Thumbnail Available
- Name:
- Rohim Hidayat _compressed.pdf
- Size:
- 174.16 KB
- Format:
- Unknown data format
- Description:
- artikel
License bundle
1 - 1 of 1
No Thumbnail Available
- Name:
- license.txt
- Size:
- 1.71 KB
- Format:
- Item-specific license agreed upon to submission
- Description: