SINTESIS DAN UJI AKTIVITAS ANTIBAKTERI SENYAWA KURKUMIN (3E,5E)-3,5-BIS(2’-HIDROKSIBENZILIDIN)-1-METILPIPERIDIN-4 -ON
| dc.contributor.author | Hasanah, U. | |
| dc.contributor.author | Zamri, A. | |
| dc.contributor.author | Balatif, N. | |
| dc.contributor.author | Eryanti, Y. | |
| dc.date.accessioned | 2014-03-27T07:09:01Z | |
| dc.date.available | 2014-03-27T07:09:01Z | |
| dc.date.issued | 2014-03-27 | |
| dc.description.abstract | The derivatives of curcumin are second ary metabolites belonging to the phenolic group. Some of them were reported to have biological activities such as anti -i nfl ammatory, anticancer and antioxidant activities. In this study, acurcumin of (3E,5E)-3,5bis(2’-hidroxybenzilidin)-1-metilpiperidin-4-one from 1-methyl-4-pi peridinone with 2-hydroxy benzaldehideh as been successfully synthesized using microwave irradiation method with NaOH (20 %) as catalyst . React ion was carried out for 1 minute at 180 watt . The compound resulted was in the form of yellow crystal withayield of 72 %. The compound was characterized by measuring its melting point, identifying by TLC, and elucidated by UV-Vis, FT- IR, MS, 1 H NMR, and 13 C NMR. Our result show edthatthecom pound had the target edmolecule structure. Ant i bacterial test was carried out using the agar di ffusion method against Staphylococcus aureus, Escherichia coli, Bacillus subtilis, and Salmonella enteritidis. Overall, inhibition zone ran ged from 6.5 t o 10 mm and showed avery weak activity. | en_US |
| dc.description.sponsorship | Zamri, A., Balatif, N., Eryanti, Y | en_US |
| dc.identifier.other | Rangga Dwijunanda Putra | |
| dc.identifier.uri | http://repository.unri.ac.id/xmlui/handle/123456789/5953 | |
| dc.language.iso | other | en_US |
| dc.subject | 1-methyl-4-piperidinone | en_US |
| dc.subject | 2-hydroxy benzaldehide | en_US |
| dc.subject | antbacterial | en_US |
| dc.subject | curcumin | en_US |
| dc.title | SINTESIS DAN UJI AKTIVITAS ANTIBAKTERI SENYAWA KURKUMIN (3E,5E)-3,5-BIS(2’-HIDROKSIBENZILIDIN)-1-METILPIPERIDIN-4 -ON | en_US |
| dc.type | Other | en_US |