SINTESIS DAN UJI TOKSISITAS ANALOG PIRAZOL 5-(4-FLUOROFENIL)-3-(NAFTALEN-2-IL)- 1-FENIL-1H-PIRAZOL

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dc.contributor.authorAstuti, Rina
dc.contributor.supervisorJasril, Jasril
dc.date.accessioned2021-08-24T04:35:39Z
dc.date.available2021-08-24T04:35:39Z
dc.date.issued2020-10
dc.description.abstractPyrazole is five ring heterocyclic compounds with two adjacent nitrogen atoms and it have two endocyclic double bonds which is known to have diverse biological activities such as anti-inflammatory, analgesic, antibacterial, antimalaria, antioxidant, and anticancer. Pyrazole analogue 5-(4-fluorophenyl)-3-(naphthalen-2-yl)-1-phenyl-1Hpyrazole (PZL-4F-AN2) was successfully synthesized through synthesis of one-pot cyclization of pyrazoline which was then followed by oxidative aromatization reaction of pyrazoline 5-(4-fluorophenyl)-3-(naphthalen-2-yl)-1-phenyl-4,5-dihydro-1Hpyrazole with glacial acetic acid by refluxing the mixture for 36 hours in the oil bath at 85oC. The purity of the compound was determined by using TLC, melting point and HPLC analysis. The structure was confirmed using UV and FTIR spectroscopy analysis. The yield of the synthesis PZL-4F-AN2 compound was 18.29%. The toxicity of pyrazole was evaluated by Brine Shrimp Lethality Test (BSLT) method with shrimp larvae (Artemia salina Leach). Pyrazole PZL-4F-AN2 had high toxicity with LC50 = 43.07 μg/mL.en_US
dc.description.sponsorship2Dosen Jurusan Kimia FMIPA Universitas Riau Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Riauen_US
dc.identifier.otherwahyu sari yeni
dc.identifier.urihttps://repository.unri.ac.id/handle/123456789/10150
dc.language.isoenen_US
dc.subjectpyrazoleen_US
dc.subjectpyrazolineen_US
dc.subjectrefluxen_US
dc.subjecttoxicityen_US
dc.titleSINTESIS DAN UJI TOKSISITAS ANALOG PIRAZOL 5-(4-FLUOROFENIL)-3-(NAFTALEN-2-IL)- 1-FENIL-1H-PIRAZOLen_US
dc.typeArticleen_US

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