SINTESIS DAN STUDI MOLECULAR DOCKING SENYAWA PIRAZOLIN DAN PIRAZOL TURUNAN 2-HIDROKSIASETOFENON DAN 2-KLOROBENZALDEHID SEBAGAI INHIBITOR ENZIM TIROSINASE

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dc.contributor.authorSianturi, Artha Tirani
dc.contributor.supervisorZamri, Adel
dc.date.accessioned2022-03-15T02:03:34Z
dc.date.available2022-03-15T02:03:34Z
dc.date.issued2021-10
dc.description.abstractThe hyperpigmentation caused by melanin production excessive on the skin. So the prevention of hyperpigmentation can be done through the use of a cream containing an inhibitor of tyrosinase. One of the compounds that have activity as inhibitors of the enzyme tyrosinase is pirazolin and pirazol. Pyrazoline and pyrazole are heterocyclic compounds containing two nitrogen atoms, that have various activities such as antimicrobial, anticancer, antidiabetic, anti-inflammatory and tyrosinase inhibitors. Pyrazoline and pyrazole derivatives of 2-hydroxyacetophenone and 2-chlorobenzaldehyde were synthesized through pyrazoline cyclization synthesis and followed by an oxidative aromatization reaction. The structure of the synthesized compounds were confirmed through spectroscopic analysis of UV, FTIR, 1H-NMR and HRMS. The yield obtained from the synthesis of pyrazoline and pyrazole compound were 65,39 % and 26,08 %. Pyrazoline and pyrazole compounds were tested for their activity as a tyrosinase inhibitor through molecular docking studies. Molecular docking studies were carried out on the crystal structure of tyrosinase (PDB ID: 2Y9X) with natural ligands tropolone and kojic acid as positive controls. The docking results show that the pyrazoline compound has a free bond energy (S score) = -10,5357 kcal/mol and the pyrazole compound has a bond free energy (S score) = -9,5256 kcal/mol while the free bond energy for kojic acid as a positive control = -8,8671 kcal/mol. This indicates that the target compounds of pyrazoline and pyrazole are predicted to be potential tyrosinase enzyme inhibitors.en_US
dc.description.sponsorshipDosen Bidang Kimia Organik Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Riauen_US
dc.identifier.otherwahyu sari yeni
dc.identifier.urihttps://repository.unri.ac.id/handle/123456789/10480
dc.language.isoenen_US
dc.publisherperpustakaan URen_US
dc.subjectdockingen_US
dc.subjectpyrazoleen_US
dc.subjectpyrazolineen_US
dc.titleSINTESIS DAN STUDI MOLECULAR DOCKING SENYAWA PIRAZOLIN DAN PIRAZOL TURUNAN 2-HIDROKSIASETOFENON DAN 2-KLOROBENZALDEHID SEBAGAI INHIBITOR ENZIM TIROSINASEen_US
dc.typeArticleen_US

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