SINTESIS DAN UJI AKTIVITAS TOKSISITAS SENYAWA ANALOG KALKON TURUNAN 2’-METOKSIASETOFENON

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dc.contributor.authorJunior, Ronaldo
dc.contributor.authorZamri, Adel
dc.contributor.authorEryanti, Yum
dc.date.accessioned2016-10-12T04:33:20Z
dc.date.available2016-10-12T04:33:20Z
dc.date.issued2016-10-12
dc.description.abstractChalcone is one of secondary metabolites from flavonoids group that have been reported to posses many biological activities such as antimicrobial, antitumor, antioxidant, anti-inflammatory, antimalari and anticancer. Chalcone generally can be synthesized by Claisen-Schmidt condensation from aldehide and ketone aromatic using acid or base catalyst. Three hydroxy analogues chalcone i.e., (E)-3-(2-hidroksifenil)-1- (2’-metoksifenil)prop-2-en-1-on, (E)-3-(3-hidroksifenil)-1-(2’-metoksifenil)prop-2-en- 1-on and (E)-3-(4-hidroksifenil)-1-(2’-metoksifenil)prop-2-en-1-on have been synthesized under microwave irradiation by using pottasium hydroxide as catalyst. The structure of those compounds were characterized based on the interpretation of spectroscopic data included UV, FTIR, 1H-NMR and HRMS. Their toxicity activity were determined by using the Brine Shrimp Lethality Test method againts larvae of Artemia salina Leach and showed high activity with LC50 value was 66,59 μg/mL, 107,45 μg/mL and 449,44 μg/mL, respectivel. It indicated that chalcone analogues were potential as anticanceren_US
dc.description.sponsorshipFakultas Matematika dan Ilmu Pengetahuan Alam Universitas Riauen_US
dc.identifier.otherwahyu sari yeni
dc.identifier.urihttp://repository.unri.ac.id/xmlui/handle/123456789/8693
dc.language.isoenen_US
dc.subjectBrine Shrimp Lethality Testen_US
dc.subjectmicrowaveen_US
dc.subjectchalconeen_US
dc.titleSINTESIS DAN UJI AKTIVITAS TOKSISITAS SENYAWA ANALOG KALKON TURUNAN 2’-METOKSIASETOFENONen_US
dc.typestudent Paper Post Degreeen_US

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