SINTESIS DAN STUDI IN SILICO SENYAWA PIRAZOLIN 2-(5-(3- BROMOFENIL)-1-FENIL-4,5-DIHIDRO-1H-PIRAZOL-3- IL)NAFTALEN-1-OL) SEBAGAI KANDIDAT ANTIKANKER PAYUDARA

Simple item page
dc.contributor.authorAnakri, Yasendi
dc.contributor.supervisorJasril, Jasril
dc.date.accessioned2024-02-01T03:15:15Z
dc.date.available2024-02-01T03:15:15Z
dc.date.issued2023-09
dc.description.abstractPyrazoline is a secondary metabolic compound containing five circular heterocyclic structures, comprising three carbon atoms and two nitrogen atoms positioned closely to each other. Due to its high toxicity, Pyrazoline exhibits diverse bioactivities, including antitumor and anticancer properties. Pyrazoline (2-(5-3-bromophenyl)-1-phenyl-4,5- dihydro-1H-pyrazole-3-yl)naphtalene-1-ol) has been successfully synthesized through several phases of reaction. The first phase involves the formation of chalcone 3-(3- bromophenyl)-1-(1-hydroxynaphthalene-2-yl)-2-propen-1-one by reacting the compound 1-hydroxy-2-acetylnaphthalene with 3-bromobenzaldehyde using the microwave irradiation method. Chalcone was synthesized using Claisen-Schmidt condensation reactions, resulting in a yield of 85.86%. In the subsequent step, chalcone was reacted with phenylhydrazine, leading to the desired compound in the presence of a sodium hydroxide catalyst. The synthesis of the target compound employed stirring and heating with seal tube, yielding 40.18%. The purification of the Pyrazoline compound was achieved through recrystallization. Its purity was assessed using TLC test, melting point determination, and HPLC analysis. Furthermore, the confirmation of its structure was based on spectroscopic data from UV, FTIR and LCMS. The molecular docking of PF-NH1-3Br against Estrogen α receptors revealed a free bond energy (ΔGbind) of -9,5 kcal/mol.en_US
dc.description.sponsorshipFakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Riauen_US
dc.identifier.citationPerpustakaanen_US
dc.identifier.otherElfitra
dc.identifier.urihttps://repository.unri.ac.id/handle/123456789/11273
dc.language.isoenen_US
dc.publisherElfitraen_US
dc.subjectchalconeen_US
dc.subjectpyrazolineen_US
dc.subjectsynthesisen_US
dc.titleSINTESIS DAN STUDI IN SILICO SENYAWA PIRAZOLIN 2-(5-(3- BROMOFENIL)-1-FENIL-4,5-DIHIDRO-1H-PIRAZOL-3- IL)NAFTALEN-1-OL) SEBAGAI KANDIDAT ANTIKANKER PAYUDARAen_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Yasendi Anakri_compressed.pdf
Size:
191.78 KB
Format:
Unknown data format
Description:
artikel
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Chemical