SINTESIS ONE-POT DAN UJI TOKSISITAS SENYAWA 3-(4-KLOROFENIL)-5-(2-METOKSIFENIL)-1-FENIL-4,5-DIHIDRO-PIRAZOL

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dc.contributor.authorSarah, Syarifah Siti
dc.contributor.authorZamri, Adel
dc.date.accessioned2018-03-07T08:21:31Z
dc.date.available2018-03-07T08:21:31Z
dc.date.issued2018-03-07
dc.description.abstractPyrazoline is five ring heterocyclic compounds with two adjacent nitrogen atoms which is known to have diverse biological activities such as antitoxicity, anticancer, antioxidant, antimalarial, antibacterial and antituberculosis. Pyrazoline analogue 3-(4-chlorophenyl)-5-(2-methoxyphenyl)-1-phenyl-4,5-dihydro-pyrazole (PF-4Cl-2OMe) was synthesized by microwave irradiation method using one-pot reaction involving condensation and cyclization reaction of 2-methoxybenzaldehyde, 4-chloroacetophenon and phenylhydrazine. Purity of the PF-4Cl-2OMe compound was checked on TLC test, determination of melting point and HPLC analysis. Pyrazoline compound have been characterized using UV, FTIR, and NMR spectrometers. The yield obtained from the synthesis of PF-4Cl-2OMe compound was 44.85%.The toxicity of pyrazoline were evaluated by Brine Shrimp Lethality Test (BSLT) method. Pyrazoline PF-4Cl-2OMe compound showed non-toxic activity with LC50 = 572.79 μg/mL.en_US
dc.description.sponsorshipFakultas Matematika dan Ilmu Pengetahuan Alam Universitas Riauen_US
dc.identifier.otherwahyu sari yeni
dc.identifier.urihttps://repository.unri.ac.id/xmlui/handle/123456789/9280
dc.language.isoenen_US
dc.subjectBrine Shrimp Lethalityen_US
dc.subjectTesten_US
dc.subjectmicrowaveen_US
dc.subjectpyrazolineen_US
dc.subjecttoxicityen_US
dc.titleSINTESIS ONE-POT DAN UJI TOKSISITAS SENYAWA 3-(4-KLOROFENIL)-5-(2-METOKSIFENIL)-1-FENIL-4,5-DIHIDRO-PIRAZOLen_US
dc.typeArticleen_US

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