SINTESIS ONE-POT DAN UJI TOKSISITAS SENYAWA 3-(2-KLOROFENIL)-5-(2-METOKSIFENIL)-1-FENIL-4,5-DIHIDRO-PIRAZOL

Simple item page
dc.contributor.authorArmandela, Delvan
dc.contributor.authorEryanti, Yum
dc.date.accessioned2019-01-09T05:11:42Z
dc.date.available2019-01-09T05:11:42Z
dc.date.issued2019-01-10
dc.description.abstractPyrazoline is an organic compound in alkaloid group with five-ring structure heterocyclic compound, containing three carbon atoms and two adjacent nitrogen atoms to one endocyclic double bond. Pyrazoline have various biological activities, such as antibacterial, anticancer, antiinflamatory, antidepressant, and antioxidant. The pyrazolines 3-(2-clorophenyl)-5-(2-methoxyphenyl)-1-phenyl-4,5-dihydropyrazole (PF-2Cl-2OMe) were synthesized by a one-pot three-component reaction between 2-methoxybenzaldehyde, 2-cloroacetophenone and phenylhydrazine with strong base catalyst (KOH) by microwave method. The purity of the compound was determined by the TLC test, the measurement of melting point and HPLC analysis. The structure of the synthesized compound was obtained from UV, FTIR, NMR and HRMS spectroscopy studies. It can be concluded that the optimum method to synthesize this compound is microwave method with yield of 40% and reaction time is relatively short. The toxicity of pyrazoline were evaluated by Brine Shrimp Lethality Test (BSLT) method. Pyrazoline PF-2Cl-2OMe compound showed non-toxic activity with LC50 = 226.46 μg/mL.en_US
dc.description.sponsorshipJurusan Kimia FMIPA Universitas Riau Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Riauen_US
dc.identifier.otherwahyu sari yeni
dc.identifier.urihttp://repository.unri.ac.id/handle/123456789/9559
dc.language.isoenen_US
dc.publisherwahyu sari yenien_US
dc.subjectBrine Shrimp Lethality Testen_US
dc.subjectmicrowave irradiationen_US
dc.subjectpyrazolineen_US
dc.titleSINTESIS ONE-POT DAN UJI TOKSISITAS SENYAWA 3-(2-KLOROFENIL)-5-(2-METOKSIFENIL)-1-FENIL-4,5-DIHIDRO-PIRAZOLen_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
1.12. ARTIKEL ILMIAH DELVAN-PDF.pdf
Size:
2.13 MB
Format:
Unknown data format
Description:
artikel
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Chemical