SINTESIS DAN UJI TOKSISITAS SENYAWA KALKON ANALOG 2,5-DIMETOKSIBENZALDEHID

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dc.contributor.authorHidayat, T
dc.date.accessioned2015-03-23T03:32:36Z
dc.date.available2015-03-23T03:32:36Z
dc.date.issued2015-03-23
dc.description.abstractChalcones are a class of α,ß-unsaturated carbonyl compounds that forms the central core of various naturally occurring biologically active compounds. They exhibit tremendous potential to act as a pharmacological agent. It has been reported that they were active as antioxidant, antifungal, antibacterial, antidepressant, anticancer, anti-inflammatory and other biological activities. The chalcone analogue of 2,5-dimetoxibenzaldehyde ((E)-3-(2,5-dimetoksifenil)-1-(4-hidroksifenil)prop-2-en-1-on) was synthesized and tested for its toxicity using Brine Shrimp Lethality Test (BSLT) method. The purity of compound has been tested using TLC, melting point test, analytical HPLC. It was then characterized using UV, IR, 1H-NMR and MS spectroscopy. LC50 value of toxic compound is <200μg/mL. Our result showed that (E)-3-(2,5-dimetoksifenil)-1-(4-hidroksifenil)prop-2-en-1-on compound was not potential as an anticancer since its LC50 was 1949 μg/mL.en_US
dc.description.sponsorshipA. Zamri 2, Yuharmen 2en_US
dc.identifier.otherwahyu ari yeni
dc.identifier.urihttp://repository.unri.ac.id/xmlui/handle/123456789/6886
dc.language.isoenen_US
dc.subjectchalconeen_US
dc.subjectclaisen schmidt condensationen_US
dc.subjecttoxicity testen_US
dc.titleSINTESIS DAN UJI TOKSISITAS SENYAWA KALKON ANALOG 2,5-DIMETOKSIBENZALDEHIDen_US
dc.typeUR-Student Paper Diplomaen_US

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