SINTESIS DAN UJI TOKSISITAS ANALOG 5-(3-FLUOROFENIL)-3-(NAFTALEN-2-IL)-1-FENIL- 1H-PIRAZOL

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dc.contributor.authorNurhayati, Asda
dc.contributor.supervisorJasril, Jasril
dc.date.accessioned2021-09-23T07:27:28Z
dc.date.available2021-09-23T07:27:28Z
dc.date.issued2021-01
dc.description.abstractPyrazole is an important group of five circular heterocyclic compounds containing two adjacent nitrogen atoms. Pyrazole compounds also have two endocyclic double bonds which is known to have diverse interesting biological activities such as, anticancer, antitumor and antioxidant. In this study, the pyrazole analogue 5-(3-fluorophenyl)-3- (naphthalene-2-yl)-1-phenyl-1H-pyrazole (PZL 2N-3F) was successfully synthesized through the synthesis of one-pot cyclization of pyrazoline which was then continued. By oxidative aromatization reaction of pyrazoline 5-(4-fluorophenyl)-3-(naphthalene2-yl)- 1-phenyl-4,5-dihydro-1H-pyrazole with glacial acetic acid under reflux for 42 hours. The purity of the synthesized compound was determined using the TLC, melting point and HPLC analysis. Structure identification was carried out through spectroscopic analysis of UV and FTIR. The yield obtained from the synthesis of PZL 2N-3F compound was 14.8%. The toxicity of pyrazole compounds was determined by the BSLT method using shrimp Larvae (Artemia salina Leach). The results of the BSLT for the PZL 2N-3F compound were non-toxic with an LC50 value of = 606.7 μg/mL.en_US
dc.description.sponsorshipJurusan Kimia FMIPA Universitas Riau Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Riauen_US
dc.identifier.otherwahyu sari yeni
dc.identifier.urihttps://repository.unri.ac.id/handle/123456789/10206
dc.language.isoenen_US
dc.subjectBrine Shrimp Lethality Testen_US
dc.subjectpyrazoleen_US
dc.subjectpyrazolineen_US
dc.subjectrefluxen_US
dc.subjecttoxicityen_US
dc.titleSINTESIS DAN UJI TOKSISITAS ANALOG 5-(3-FLUOROFENIL)-3-(NAFTALEN-2-IL)-1-FENIL- 1H-PIRAZOLen_US
dc.typeArticleen_US

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