SINTESIS PIRAZOLIN 5- (2-BROMOFENIL)-3-(1- HIDROKSINAFTALEN-2-IL)-1- FENIL-4,5-DIHIDRO-1H-PIRAZOL
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Date
2023-12
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Elfitra
Abstract
Pyrazoline is five ring heterocyclic compounds with two adjacent nitrogen atoms which
is known to have diverse biological activities such as antioxidant, antitumor and
anticancer agent. The synthesis of pyrazoline (5-(2- bromophenyl)-3-(1-
hydroxynaphthalene-2-yl)-1-phenyl-4,5-dihydro-1H-pyrazole begins with the formation
of chalcone by reacting 1-hydroxy-2-acetyl naphthalene with 2-bromobenzaldehide using
microwave irradiation method. The next step was reacted chalcone with phenyl
hydrazine to produce target compound used sodium hydroxide catalyst with a
monowave for 3 hours at a temperature of 80℃ and the resulting yield was
72%. The purity of the target compound was determined using TLC, melting
point and HPLC. Analysis and confirming structure based on spectroscopic data of
UV and FTIR.
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Keywords
chalcone, pyrazoline, synthesis
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