SINTESIS ANALOG 2-PIRAZOLIN DARI KALKON INTI NAFTALEN DAN UJI AKTIVITASNYA SEBAGAI ANTIBAKTERI

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dc.contributor.authorHayati, Fitrah
dc.date.accessioned2015-03-31T04:11:27Z
dc.date.available2015-03-31T04:11:27Z
dc.date.issued2015-03-31
dc.description.abstractPyrazolines have been reported to possess many of interesting biological activities such as antibacterial, antitumor, antioxidant, anti-inflammatory, antimalarial, anticancer, and anticonvulsant activity. In this research, an analog pyrazoline 5-(4-chlorophenyl)-3-(naphthalene-1-yl)-4,5-dihydro-1H-pirazol was synthesized by the reaction between 1-naphthyl chalcones and hydrazine hydrate using glacial acetic acid as catalyst under microwave irradiation. The compound showed a good yield, and then was characterized by UV, IR and 1H-NMR spectroscopy. The antibacterial activity of this compound was determined using agar diffusion method against the bacteria Escherichia coli, Salmonella typi, Bacillus subtilis and Staphylococcus aureus. The antibacterial activity were classified as very weak at concentrations of 10, 30 and 50 μg/disk with a diameter of inhibition produced of 6,2 – 8,1 mm.en_US
dc.description.sponsorshipAdel Zamri, Jasrilen_US
dc.identifier.otherwahyu sari yeni
dc.identifier.urihttp://repository.unri.ac.id/xmlui/handle/123456789/6891
dc.language.isoenen_US
dc.subject1-naphthyl chalconesen_US
dc.subjectpyrazolinesen_US
dc.subjectantibacterial activityen_US
dc.subjectagar diffusion methoden_US
dc.titleSINTESIS ANALOG 2-PIRAZOLIN DARI KALKON INTI NAFTALEN DAN UJI AKTIVITASNYA SEBAGAI ANTIBAKTERIen_US
dc.typeUR-Student Paper Diplomaen_US

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