SINTESIS DAN UJI TOKSISITAS HIDRAZON (E)-N’-((E)-3-(4- METOKSIFENIL)-1-(NAFTALEN-1-IL)ALLILIDEN)-4- METILBENZENSULFONOHIDRAZID
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Date
2022-11
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Elfitra
Abstract
Hydrazone is an imine-derived compound that has various biological activities, such as
anticancer, antimalarial, antimicrobial, and antioxidant,. Hydrazone compound (E)-N'-
((E)-3-(4-methoxyphenyl)-1-(naphthalen-1-il)alliliden)-4-methylbenzensulfonohidrazid
(HDZ-1-NFT-4-TSH) has been successfully synthesized. Begins with the formation of
chalcone (E)-3-(4-methoxyphenyl)-1-(naphtalene-1-yl)-prop-2-en-1-one by reacting
1-acetylnaphtalene and 4-methoxybenzaldhyde with KOH 3N as catalyst then produced
yield 29.70%. The next step was reacted chalcone and p-toluensulfonyl hydrazine with
HCl 3N as catalyst then produced yield 77.87%. The hydrazone compound was tested
with TLC test, melting point and HPLC analysis. The compound was analyzed by
UV-Vis and FTIR spectrophotometer. The toxicity of the compound was evaluated by
BSLT (brine shrimp lethality test) method using Artemia salina Leach larvae. The test
results showed that the hydrazone compound was non-toxic with LC50 value of
251,18 μg/mL.
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Keywords
hydrazone, synthesis, toxicity
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