SINTESIS DAN STUDI MOLECULAR DOCKING SENYAWA 3-(3-3- METOKSIFENIL)-1-FENIL-4,5-DIHIDRO- 1H-PIRAZOL-5-IL) FENOL SEBAGAI INHIBITOR ENZIM TIROSINASE

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dc.contributor.authorApriyani, Yuhana
dc.contributor.supervisorZamri, Adel
dc.date.accessioned2022-08-02T07:37:34Z
dc.date.available2022-08-02T07:37:34Z
dc.date.issued2022-03
dc.description.abstractHyperpigmentation is a darkening of the skin color caused by an increase in melanin production. Darkening of the skin occurs due to the formation of the pigment melanin in the skin through the oxidation of tyrosine which is assisted by the enzyme tyrosinase L-DOPA which will eventually form the pigment melanin. In general, the amount of melanin in the skin will determine our skin color. Tyrosinase is an enzyme that regulates melanin biosynthesis. Melanin formation can be inhibited by reducing tyrosinase synthesis or inhibiting its activity. One of the compounds that has acted an inhibitor of the tyrosinase enzyme is pyrazoline. Pyrazoline is a heterocyclic compound with two nitrogen atoms adjacent in a ring of five. The compound 3-(3-3- methoxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole-5-yl)phenol was synthesized using a monowave apparatus. The purity of the target compound was analyzed by TLC test, melting point measurement, and HPLC. The synthesized compounds were then structurally confirmed by UV, FTIR, 1H-NMR, and HRMS spectroscopy. The yield obtained from the synthesis of pyrazoline compounds is 75%. The synthesized pure compound was tested for activity as a tyrosinase inhibitor by molecular docking (in silico) and in vitro studies. Molecular docking studies were carried out on the crystal structure of tyrosinase (PDB ID: 2Y9X) with natural ligands tropolone and kojic acid as positive controls. The docking results showed that the pyrazoline compound had free bond energy (S score) = -11.0206 kcal/mol, while the free bond energy for kojic acid was -7.4610 kcal/mol.en_US
dc.description.sponsorshipFakultas Matematika dan Ilmu Pengetahuan Alam Universitas Riauen_US
dc.identifier.citationPerpustakaanen_US
dc.identifier.issnElfitra
dc.identifier.urihttps://repository.unri.ac.id/handle/123456789/10637
dc.language.isoenen_US
dc.publisherElfitraen_US
dc.subjectdockingen_US
dc.subjectpyrazolineen_US
dc.subjectsynthesisen_US
dc.subjecttyrosinaseen_US
dc.titleSINTESIS DAN STUDI MOLECULAR DOCKING SENYAWA 3-(3-3- METOKSIFENIL)-1-FENIL-4,5-DIHIDRO- 1H-PIRAZOL-5-IL) FENOL SEBAGAI INHIBITOR ENZIM TIROSINASEen_US
dc.typeArticleen_US

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