Abstract:
Chalcones are l,3-diphenyl-2-propene-l-one, in which two aromatic rings
are Unked by a three carbon a,P-unsaturated carbonyl system.These are abundant
in edible plants and are considered to be precursors of flavonoids and
isoflavonoids. A number of chalcones have been reported to possess
anti-bacterial, antiulcer, antifungal, antioxidant, and antimalarial. Appreciation of
these findings motivated me to synthesize chalcones as a potential template for
antimicrobial agents. In the present investigation I have carried out the synthesis
of two substituted 4'-kloro chalcones by claisen-schimdt condensation. This
reaction is carried out in presence of base like NaOH by grinding method. The
reaction can be easily carried out under solvent free condition so as to minimize
the pollution. The structures of these compounds have been investigated by
nuclear magnetic resonance spectroscopy. The antimicrobial activity of the
products was evaluated by Fiher Paper Disc diffusion Method. The compound Ci
showed excellent activity against S. aureus at concentration 20 ng/disc.
