Effects Of Hypochlorous Ach) On Oxidative Dna Damage In Human Alveolar Epithelial Cells

Abstract

Inflammation induced by biological, chemical, and physiological factors has long been associated with increased risk of human cancer in various organs (Coussens and Werb 2002). Epidemiological studies indicate a strong relationship between inflammation and carcinogenesis. For example, individuals with long-standing extensive ulcerative colitis and Crohn's disease have a significant risk of colorectal cancer (Siegel and Sands 2006), chronic hepatitis B and C infections in the liver predispose to hepatocellular carcinoma (Barazani, Hiatt et al. 2007), and Helicobacter pylori infection has been established to have a causal relationship to gastric cancer (Peter and Beglinger 2007). Within the lung, chronic inflammatory diseases, such as idiopathic pulmonary fibrosis, systemic sclerosis, certain pneumoconiosis and chronic obstructive pulmonary disease (COPD), have been implicated to limg carcinogenesis (Brody and Spira 2006).